Anti-MBNL3抗体(ab96179)
Key features and details
- Rabbit polyclonal to MBNL3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-MBNL3抗体
参阅全部 MBNL3 一抗 -
描述
兔多克隆抗体to MBNL3 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment, corresponding to a sequence within amino acids 1-267 of Human MBNL3.
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阳性对照
- 293T, A431, HeLaS3, HepG2, Molt4 and Raji whole cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96179于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 39 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 39 kDa. |
靶标
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功能
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. -
组织特异性
Highly expressed in the placenta. -
序列相似性
Belongs to the muscleblind family.
Contains 4 C3H1-type zinc fingers. -
细胞定位
Nucleus. Cytoplasm. Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts. - Information by UniProt
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数据库链接
- Entrez Gene: 55796 Human
- Entrez Gene: 171170 Mouse
- Entrez Gene: 302492 Rat
- Omim: 300413 Human
- SwissProt: Q9NUK0 Human
- SwissProt: Q8R003 Mouse
- Unigene: 105134 Human
- Unigene: 596347 Human
see all -
别名
- A530038J18Rik antibody
- AI661274 antibody
- CHCR antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab96179 尚未被引用在任何文献中。