Anti-Maxi Potassium channel beta/KCNMB1抗体(ab3587)
Key features and details
- Rabbit polyclonal to Maxi Potassium channel beta/KCNMB1
- Isotype: IgG
概述
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产品名称
Anti-Maxi Potassium channel beta/KCNMB1抗体 -
描述
兔多克隆抗体to Maxi Potassium channel beta/KCNMB1 -
宿主
Rabbit -
特异性
ab3587 is specific for the Beta-1 subunit of Maxi K+. It does not detect the beta-2 subunit -
种属反应性
预测可用于: Mouse, Rat, Cow, Dog, Human
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免疫原
Synthetic peptide corresponding to Human Maxi Potassium channel beta/KCNMB1 aa 90-103.
Sequence:LYHTEDTRDQNQQC
(Peptide available asab5023) -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
Primary antibody说明
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
靶标
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功能
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. -
组织特异性
Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. -
序列相似性
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. -
翻译后修饰
N-glycosylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3779 Human
- Entrez Gene: 16533 Mouse
- Entrez Gene: 29747 Rat
- Omim: 603951 Human
- SwissProt: Q16558 Human
- SwissProt: Q8CAE3 Mouse
- SwissProt: P97678 Rat
- Unigene: 484099 Human
see all -
别名
- BK channel beta subunit antibody
- BK channel subunit beta 1 antibody
- BK channel subunit beta-1 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (17)
ab3587 被引用在 17 文献中.
- Sun WT et al. Homocysteine alters vasoreactivity of human internal mammary artery by affecting the KCa channel family. Ann Transl Med 9:625 (2021). PubMed: 33987323
- Beck L et al. Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice. Front Pharmacol 11:619152 (2020). PubMed: 33643042
- Lu T et al. Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. Cardiovasc Res 115:145-153 (2019). PubMed: 29850792
- Nystoriak MA et al. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal 10:N/A (2017). PubMed: 28119464
- Nieves-Cintrón M et al. Impaired BKCachannel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep 7:14058 (2017). PubMed: 29070899