Anti-MACC1抗体(ab226803)
Key features and details
- Rabbit polyclonal to MACC1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-MACC1抗体
参阅全部 MACC1 一抗 -
描述
兔多克隆抗体to MACC1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment within Human MACC1 (N terminal). The exact sequence is proprietary.
Database link: Q6ZN28 -
阳性对照
- WB: A431 whole cell extract.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab226803于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 96 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 96 kDa. |
靶标
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功能
Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo. -
组织特异性
Preferentially expressed in metastasizing tumors. -
序列相似性
Contains 1 SH3 domain. -
细胞定位
Cytoplasm. Nucleus. Mainly found in the cytoplasm in non-metastasizing tumors. - Information by UniProt
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数据库链接
- Entrez Gene: 346389 Human
- Entrez Gene: 612646 Human
- SwissProt: Q6ZN28 Human
- Unigene: 598388 Human
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别名
- 7A5 antibody
- MACC1 antibody
- MACC1_HUMAN antibody
see all
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab226803 被引用在 6 文献中.
- Mei J et al. MACC1 regulates the AKT/STAT3 signaling pathway to induce migration, invasion, cancer stemness, and suppress apoptosis in cervical cancer cells. Bioengineered 13:61-70 (2022). PubMed: 34939526
- Zhang T et al. Hsa_circ_0005100 regulates tumorigenicity of colorectal carcinoma via miR-145-5p/MACC1 axis. J Clin Lab Anal 36:e24533 (2022). PubMed: 35766445
- Xiong M et al. MACC1 Promotes the Progression and Is a Novel Biomarker for Predicting Immunotherapy Response in Colorectal Cancer. J Oncol 2022:8326940 (2022). PubMed: 35874635
- Chen H et al. Long Intergenic Non-Coding RNA LINC00885 Promotes Tumorigenesis of Cervical Cancer by Upregulating MACC1 Expression Through Serving as a Competitive Endogenous RNA for microRNA-432-5p. Cancer Manag Res 13:1435-1447 (2021). PubMed: 33603486
- Zhang YM et al. miR-34a and miR-125a-5p inhibit proliferation and metastasis but induce apoptosis in hepatocellular carcinoma cells via repressing the MACC1-mediated PI3K/AKT/mTOR pathway. Neoplasma 67:1042-1053 (2020). PubMed: 32484698
- Liu D et al. Long Intergenic Non-Protein Coding RNA 519 Promotes the Biological Activities of Tongue Squamous Cell Carcinoma by Sponging microRNA-876-3p and Consequently Upregulating MACC1. Onco Targets Ther 13:11975-11990 (2020). PubMed: 33244240