Anti-Leptin Receptor抗体(ab92615)
Key features and details
- Chicken polyclonal to Leptin Receptor
- Suitable for: IHC-FoFr
- Reacts with: Rat
- Isotype: IgY
概述
-
产品名称
Anti-Leptin Receptor抗体
参阅全部 Leptin Receptor 一抗 -
描述
鸡多克隆抗体to Leptin Receptor -
宿主
Chicken -
经测试应用
适用于: IHC-FoFrmore details -
种属反应性
与反应: Rat -
免疫原
Recombinant full length protein. This information is proprietary to Abcam and/or its suppliers.
-
阳性对照
- IHC-Fr: Rat intestine, Rat brainstem
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
-
纯度
Protein L purified -
克隆
多克隆 -
同种型
IgY -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab92615于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IHC-FoFr |
说明 |
---|
IHC-FoFr: 1/100 - 1/600.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
-
功能
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. -
组织特异性
Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. -
序列相似性
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 4 fibronectin type-III domains.
Contains 1 Ig-like (immunoglobulin-like) domain. -
结构域
The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
翻译后修饰
On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 24536 Rat
- SwissProt: Q62959 Rat
- Unigene: 9891 Rat
-
别名
- CD 295 antibody
- CD295 antibody
- CD295 antigen antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (0)
ab92615 尚未被引用在任何文献中。