Anti-Laminin抗体[MEC5] (ab2466)
Key features and details
- Rat monoclonal [MEC5] to Laminin
- Reacts with: Mouse, Rat, Human
- Isotype: IgG1
概述
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产品名称
Anti-Laminin抗体[MEC5]
参阅全部 Laminin 一抗 -
描述
大鼠单克隆抗体[MEC5] to Laminin -
宿主
Rat -
特异性
This antibody reacts with the P1 fragment of laminin. -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Full length native protein (purified) corresponding to Rat Laminin. ab2466 was derived from DZB rats that had developed membranous glomerulopathy upon exposure to mercuric chloride
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Concentration information loading...
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纯度
Tissue culture supernatant -
克隆
单克隆 -
克隆编号
MEC5 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
靶标
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功能
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. -
组织特异性
Broadly expressed in: skin, heart, lung, and the reproductive tracts. -
序列相似性
Contains 11 laminin EGF-like domains.
Contains 1 laminin IV type A domain.
Contains 1 laminin N-terminal domain. -
结构域
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular. -
细胞定位
Secreted > extracellular space > extracellular matrix > basement membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 10319 Human
- Entrez Gene: 284217 Human
- Entrez Gene: 3908 Human
- Entrez Gene: 3912 Human
- Entrez Gene: 3913 Human
- Entrez Gene: 3915 Human
- Entrez Gene: 3918 Human
- Entrez Gene: 16772 Mouse
see all -
别名
- LAMA 1 antibody
- LAMA antibody
- LAMA1 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab2466 被引用在 2 文献中.
- Berthod F et al. Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. J Cell Physiol 227:2130-7 (2012). IHC-Fr ; Human . PubMed: 21769871
- Aten J et al. Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Am J Pathol 146:1467-80 (1995). PubMed: 7778685