Key features and details
- Rat monoclonal [MEC5] to Laminin
- Reacts with: Mouse, Rat, Human
- Isotype: IgG1
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
参阅全部 Laminin 一抗
描述大鼠单克隆抗体[MEC5] to Laminin
特异性This antibody reacts with the P1 fragment of laminin.
种属反应性与反应: Mouse, Rat, Human
Full length native protein (purified) corresponding to Rat Laminin. ab2466 was derived from DZB rats that had developed membranous glomerulopathy upon exposure to mercuric chloride
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Concentration information loading...
纯度Tissue culture supernatant
功能Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
组织特异性Broadly expressed in: skin, heart, lung, and the reproductive tracts.
序列相似性Contains 11 laminin EGF-like domains.
Contains 1 laminin IV type A domain.
Contains 1 laminin N-terminal domain.
结构域The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain IV is globular.
细胞定位Secreted > extracellular space > extracellular matrix > basement membrane.
- Information by UniProt
- LAMA 1 antibody
- LAMA antibody
- LAMA1 antibody
ab2466 被引用在 4 文献中.
- Yue F et al. PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy. Mol Ther 29:132-148 (2021). PubMed: 33068545
- Wen X et al. Evaluation of the Effects of Solvents Used in the Fabrication of Microfluidic Devices on Cell Cultures. Micromachines (Basel) 12:N/A (2021). PubMed: 34066183
- Berthod F et al. Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. J Cell Physiol 227:2130-7 (2012). IHC-Fr ; Human . PubMed: 21769871
- Aten J et al. Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Am J Pathol 146:1467-80 (1995). PubMed: 7778685