Anti-Kallikrein 7/KLK7抗体(ab200745)
Key features and details
- Rabbit polyclonal to Kallikrein 7/KLK7
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
概述
-
产品名称
Anti-Kallikrein 7/KLK7抗体
参阅全部 Kallikrein 7/KLK7 一抗 -
描述
兔多克隆抗体to Kallikrein 7/KLK7 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human -
免疫原
Synthetic peptide within Human Kallikrein 7/KLK7 aa 1-100. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P49862 -
阳性对照
- HEK293T, sp2/0 and PC12 whole cell lysate
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.097% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
纯度
Immunogen affinity purified -
纯化说明
Purity is > 95% (by SDS-PAGE). -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab200745于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 28 kDa.
|
说明 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 28 kDa. |
靶标
-
功能
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-
-Cys-7', '16-Tyr-
-Leu-17', '25-Phe-
-Tyr-26' and '26-Tyr-
-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. -
组织特异性
Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). -
序列相似性
Belongs to the peptidase S1 family. Kallikrein subfamily.
Contains 1 peptidase S1 domain. -
细胞定位
Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. - Information by UniProt
-
数据库链接
- Entrez Gene: 5650 Human
- Entrez Gene: 23993 Mouse
- Entrez Gene: 292852 Rat
- Omim: 604438 Human
- SwissProt: P49862 Human
- SwissProt: Q91VE3 Mouse
- SwissProt: P36373 Rat
- Unigene: 151254 Human
see all -
别名
- Chymotryptic stratum corneum antibody
- hK 7 antibody
- hK7 antibody
see all
图片
数据表及文件
-
Datasheet download
文献 (1)
ab200745 被引用在 1 文献中.
- Zhang Y et al. LncRNA FOXD2-AS1 accelerates the papillary thyroid cancer progression through regulating the miR-485-5p/KLK7 axis. J Cell Biochem 120:7952-7961 (2019). PubMed: 30456805