Key features and details
- Rabbit polyclonal to ITPR2
- Suitable for: IHC-Fr
- Reacts with: Mouse, Rat, Human, Amphibian, Salamander
- Isotype: IgG
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS
Concentration information loading...
纯度Immunogen affinity purified
Immunizing Peptide (Blocking)
Our Abpromise guarantee covers the use of ab5805 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
功能Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
组织特异性Isoform Short is found in skeletal muscle and heart.
疾病相关Anhidrosis, isolated, with normal sweat glands
序列相似性Belongs to the InsP3 receptor family.
Contains 5 MIR domains.
结构域The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
翻译后修饰Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.
细胞定位Endoplasmic reticulum membrane.
- Information by UniProt
- 4 antibody
- 5-trisphosphate receptor antibody
- Inositol 1 4 5 trisphosphate receptor type 2 antibody
ab5805 被引用在 2 文献中.
- Causton B et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol 59:684-694 (2018). PubMed: 29958012
- Okamoto Y et al. Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes. J Mol Cell Cardiol 52:988-97 (2012). ICC/IF ; Rat . PubMed: 22285480