Anti-IRS1抗体(ab5603)

Submit a review Submit a question References (32)

Key features and details

  • Rabbit polyclonal to IRS1
  • Reacts with: Mouse
  • Isotype: IgG

概述

  • 产品名称

    Anti-IRS1抗体
    参阅全部 IRS1 一抗

  • 描述

    兔多克隆抗体to IRS1

  • 宿主

    Rabbit

  • 种属反应性

    与反应: Mouse
    预测可用于: Rat, Chicken, Human, Xenopus laevis, African green monkey

  • 免疫原

    Synthetic peptide corresponding to Human IRS1 aa 602-615.
    Sequence:

    LHTDDGYMPMSPGV

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

靶标

  • 功能

    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

  • 疾病相关

    Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].

  • 序列相似性

    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.

  • 翻译后修饰

    Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
    Phosphorylation of Tyr-896 is required for GRB2-binding.
  • Information by UniProt

  • 数据库链接

    see all

  • 别名

    • HIRS 1 antibody
    • HIRS1 antibody
    • Insulin receptor substrate 1 antibody
    • IRS 1 antibody
    • IRS-1 antibody
    • IRS1 antibody
    • IRS1_HUMAN antibody
    • OTTHUMP00000164234 antibody
    see all

文献 (32)

发表研究结果有使用 ab5603？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab5603 被引用在 32 文献中.

  • Han D  et al. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation. Sci Rep 10:7041 (2020). PubMed: 32341445
  • de Lucia C  et al. Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. Commun Biol 3:157 (2020). PubMed: 32242137
  • Wang B  et al. Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics. Mol Med Rep 21:2051-2062 (2020). PubMed: 32186775
  • Hermida-Prado F  et al. The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. J Clin Med 8:N/A (2019). PubMed: 31382448
  • Lombino FL  et al. The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis. Sci Rep 9:15940 (2019). PubMed: 31685876
View all Publications for this product

客户评价及客户问答

Show All 评价 Q&A
提交评价 提交问题

There are currently no Customer reviews or Questions for ab5603.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com