Anti-ILT-3抗体(ab129772)
Key features and details
- Rabbit polyclonal to ILT-3
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ILT-3抗体
参阅全部 ILT-3 一抗 -
描述
兔多克隆抗体to ILT-3 -
宿主
Rabbit -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human ILT-3 (internal sequence).
Database link: Q8NHJ6 -
阳性对照
- A549 cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 48% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS does not contain Mg2+ or Ca2+ -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab129772 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129772于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/100 - 1/500.
|
说明 |
---|
ICC/IF
1/100 - 1/500. |
靶标
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功能
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. -
组织特异性
Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. -
序列相似性
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
结构域
Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. -
细胞定位
Cell membrane. Ligand binding leads to internalization and translocation to an antigen-processing compartment. - Information by UniProt
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数据库链接
- Entrez Gene: 11006 Human
- Omim: 604821 Human
- SwissProt: Q8NHJ6 Human
- Unigene: 67846 Human
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别名
- CD85 antigen-like family member K antibody
- CD85k antibody
- HM18 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab129772 尚未被引用在任何文献中。