Anti-IL-15RA抗体(ab183113)
Key features and details
- Rabbit polyclonal to IL-15RA
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-IL-15RA抗体
参阅全部 IL-15RA 一抗 -
描述
兔多克隆抗体to IL-15RA -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human IL-15RA aa 250 to the C-terminus. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_002180 -
阳性对照
- Human liver cancer tissue lysate; Human colon cancer tissue lysate; Human fetal kidney tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+ -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab183113于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/5000. Predicted molecular weight: 28 kDa.
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说明 |
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WB
1/1000 - 1/5000. Predicted molecular weight: 28 kDa. |
靶标
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功能
Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK. -
组织特异性
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. -
序列相似性
Contains 1 Sushi (CCP/SCR) domain. -
翻译后修饰
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Phosphorylated by activated SYK.
N-glycosylated and O-glycosylated. -
细胞定位
Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3601 Human
- Omim: 601070 Human
- SwissProt: Q13261 Human
- Unigene: 524117 Human
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别名
- AA690181 antibody
- CD215 antibody
- I15RA_HUMAN antibody
see all
图片
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All lanes : Anti-IL-15RA antibody (ab183113) at 1/200 dilution
Lane 1 : Human liver cancer tissue lysate
Lane 2 : Human colon cancer tissue lysate
Lane 3 : Human fetal kidney tissue lysate
Lysates/proteins at 30 µg per lane.
Secondary
All lanes : Goat Anti-rabbit HRP at 1/10000 dilution
Predicted band size: 28 kDa
Exposure time: 1 minute
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab183113 尚未被引用在任何文献中。