IEM-1460,GluR2 lacking AMPA receptor blocker (ab141507)
Key features and details
- Selective GluR2 lacking AMPA receptor blocker. Open channel blocker.
- CAS Number: 121034-89-7
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
IEM-1460,GluR2 lacking AMPA receptor blocker -
描述
Selective GluR2 lacking AMPA receptor blocker. Open channel blocker. -
生物学描述
Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS编号
121034-89-7 -
化学结构
性能
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化学名称
N,N,N-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide hydrobromide -
分子量
454.33 -
分子式
C19H37BrN2.HBr -
PubChem识别号
6604954 -
存放说明
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in water to 100 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-] -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (3)
ab141507 被引用在 3 文献中.
- Livingstone RW et al. Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors. Front Mol Neurosci 14:660208 (2021). PubMed: 33867938
- Li X et al. A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2. Cell Rep 34:108741 (2021). PubMed: 33596426
- Glasgow SD et al. Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus. Cell Rep 25:168-182.e6 (2018). PubMed: 30282026