参阅全部 TPH2 蛋白酶
氨基酸37 to 50
Our Abpromise guarantee covers the use of ab45838 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
通路Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
疾病相关Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
序列相似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.
- Information by UniProt
ab45838 has not yet been referenced specifically in any publications.