抗人IgM抗体[R1/69] (ab17104)
Key features and details
- Mouse monoclonal [R1/69] to Human IgM
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
抗人IgM抗体[R1/69]
参阅全部 Human IgM 一抗 -
描述
小鼠单克隆抗体[R1/69] to人IgM -
宿主
Mouse -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Human Human IgM.
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阳性对照
- Tonsil
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常规说明
This antibody reacts with the heavy chain present in all types of human IgM.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
Concentration information loading...
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纯度
Tissue culture supernatant -
Primary antibody说明
This antibody reacts with the heavy chain present in all types of human IgM. -
克隆
单克隆 -
克隆编号
R1/69 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab17104于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/25 - 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.
1/25 - 1/50 in an ABC method. We suggest an incubation period of 30 minutes at room temperature. |
说明 |
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IHC-P
1/25 - 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. 1/25 - 1/50 in an ABC method. We suggest an incubation period of 30 minutes at room temperature. |
靶标
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相关性
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. -
细胞定位
Cell Membrane and Secreted -
数据库链接
- Entrez Gene: 3507 Human
- Omim: 147020 Human
- SwissProt: P01871 Human
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别名
- Immunoglobin heavy chain constant region mu antibody
- AGM1 antibody
- Constant region of heavy chain of IgM antibody
see all
图片
数据表及文件
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Datasheet download
文献 (1)
ab17104 被引用在 1 文献中.
- Tang J et al. Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma. Genes Dis 6:407-418 (2019). PubMed: 31832521