抗人IgM抗体[2B9] (ab1947)
Key features and details
- Mouse monoclonal [2B9] to Human IgM
- Suitable for: ELISA, Conjugation
- Reacts with: Human
- Isotype: IgG2b
概述
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产品名称
抗人IgM抗体[2B9]
参阅全部 Human IgM 一抗 -
描述
小鼠单克隆抗体[2B9] to人IgM -
宿主
Mouse -
特异性
Mu-chain of human IgM, Fc-region localized epitope
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经测试应用
适用于: ELISA, Conjugationmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (purified) corresponding to Human Human IgM.
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常规说明
Concentration varies from lot to lot and can be provided on request.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Purity tested by electrophoresis. -
克隆
单克隆 -
克隆编号
2B9 -
骨髓瘤
Sp2/0 -
同种型
IgG2b -
研究领域
应用
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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Conjugation |
Use at an assay dependent concentration.
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说明 |
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ELISA
Use at an assay dependent concentration. |
Conjugation
Use at an assay dependent concentration. |
靶标
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相关性
IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. -
细胞定位
Cell Membrane and Secreted -
数据库链接
- Entrez Gene: 3507 Human
- Omim: 147020 Human
- SwissProt: P01871 Human
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别名
- Immunoglobin heavy chain constant region mu antibody
- AGM1 antibody
- Constant region of heavy chain of IgM antibody
see all
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab1947 被引用在 1 文献中.
- Sun C et al. Mobile phone signal exposure triggers a hormesis-like effect in Atm(+/+) and Atm(-/-) mouse embryonic fibroblasts. Sci Rep 6:37423 (2016). PubMed: 27857169