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Immunology Immunoglobulins Heavy Chain IgG

抗人IgG抗体(ab2410)

  • Datasheet
  • SDS
Submit a review Q&A (7)References (36)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Human IgG antibody (ab2410)

    Key features and details

    • Rabbit polyclonal to Human IgG
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: unknown

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    概述

    • 产品名称

      抗人IgG抗体
      参阅全部 Human IgG 一抗
    • 描述

      兔多克隆抗体to人IgG
    • 宿主

      Rabbit
    • 经测试应用

      适用于: IHC-Pmore details
    • 种属反应性

      与反应: Human
    • 免疫原

      IgG isolated from a pool of normal human sera.

    • 常规说明

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • 存储溶液

      Preservative: 0.05% Sodium azide
      Constituent: 1% BSA
    • Concentration information loading...
    • 纯度

      Proprietary Purification
    • 克隆

      多克隆
    • 同种型

      unknown
    • 轻链类型

      unknown
    • 研究领域

      • Immunology
      • Immunoglobulins
      • Heavy Chain
      • IgG

    相关产品

    • ChIP Related Products

      • ChIP Kit (ab500)
    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Related Products

      • Native Human IgG protein (ab98981)

    应用

    Our Abpromise guarantee covers the use of ab2410 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    IHC-P 1/200 - 1/500. Perform enzymatic antigen retrieval before commencing with IHC staining protocol.

    靶标

    • 相关性

      IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).
    • 细胞定位

      Cell Membrane and Secreted
    • 数据库链接

      • Entrez Gene: 3500 Human
      • Entrez Gene: 3501 Human
      • Entrez Gene: 3502 Human
      • Entrez Gene: 3503 Human
      • Omim: 147100 Human
      • Omim: 147110 Human
      • Omim: 147120 Human
      • Omim: 147130 Human
      • SwissProt: P01857 Human
      • SwissProt: P01859 Human
      • SwissProt: P01860 Human
      • SwissProt: P01861 Human
      • Unigene: 510635 Human
      see all
    • 别名

      • FLJ39988 antibody
      • FLJ40036 antibody
      • FLJ40253 antibody
      • FLJ40587 antibody
      • FLJ40789 antibody
      • FLJ40834 antibody
      • G1m marker antibody
      • G2m marker antibody
      • G3m marker antibody
      • G4m marker antibody
      • HDC antibody
      • Heavy chain disease protein antibody
      • Human immunglobulin G antibody
      • Ig gamma 1 chain C region antibody
      • Ig gamma 2 chain C region antibody
      • Ig gamma 3 chain C region antibody
      • Ig gamma 4 chain C region antibody
      • IgG heavy chain locus antibody
      • IGHG 1 antibody
      • IGHG 2 antibody
      • IGHG 3 antibody
      • IGHG 4 antibody
      • IGHG1 antibody
      • IGHG2 antibody
      • IGHG3 antibody
      • IGHG4 antibody
      • Immunoglobulin Gm1 antibody
      • Immunoglobulin Gm3 antibody
      • Immunoglobulin Gm4 antibody
      • immunoglobulin heavy constant gamma 1 (G1m marker) antibody
      • Immunoglobulin heavy constant gamma 1 antibody
      • immunoglobulin heavy constant gamma 2 (G2m marker) antibody
      • Immunoglobulin heavy constant gamma 2 antibody
      • immunoglobulin heavy constant gamma 3 (G3m marker) antibody
      • Immunoglobulin heavy constant gamma 3 antibody
      • immunoglobulin heavy constant gamma 4 (G4m marker) antibody
      • Immunoglobulin heavy constant gamma 4 antibody
      • MGC117419 antibody
      • MGC45809 antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Human IgG antibody (ab2410)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Human IgG antibody (ab2410)
      ab2410 staining IgG in human tonsil sections

    实验方案

    • Immunohistochemistry protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet
    • SDS
  • 文献 (36)

    发表研究结果有使用 ab2410?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2410 被引用在 36 文献中.

    • Liu Z  et al. Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. Oncogenesis 9:39 (2020). PubMed: 32291386
    • Dai L  et al. Knockdown of long non-coding RNA LINC00176 suppresses ovarian cancer progression by BCL3-mediated down-regulation of ceruloplasmin. J Cell Mol Med 24:202-213 (2020). PubMed: 31668012
    • Wang Y  et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol 21:274-286 (2020). PubMed: 32066947
    • Wei Z  et al. Molecular Mechanism of Mesenchyme Homeobox 1 in Transforming Growth Factor ß1-Induced P311 Gene Transcription in Fibrosis. Front Mol Biosci 7:59 (2020). PubMed: 32411720
    • Wang X  et al. Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling. Life Sci 230:162-168 (2019). PubMed: 31125562
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-7 of 7 Abreviews or Q&A

    Question

    Has this antibody ever been tested for IHC-P to detect immune deposits in human skin biopsies for the diagnosis of autoimmune diseases like lupus erythematosus?

    Read More

    Abcam community

    Verified customer

    Asked on Jul 11 2012

    Answer

    We have not received any report of the this antibody being used for diagnosis of autoimmune diseases by IHC or other methods. It has been demonstrated to be capable of staining a sub-population of cells in tonsil sections, as shown on the datasheet, but detection of immune deposits of immunoglobulins may requirea more sensitive tecnique. If you do decide to try this antibody, please contact us if you have any difficulty.

    Read More

    Abcam Scientific Support

    回复于 Jul 11 2012

    Question

    Ab2410 does not bind to human IgG light chain on a Western blot, but it does bind to the heavy chain.
    Looking for a rabbit anti-human IgG (H&L) antibody, a mouse anti-human IgG (H&L) antibody, and an anti-mouse IgG (H&L) antibody conjugated to AP.

    Read More

    Abcam community

    Verified customer

    Asked on Jul 10 2012

    Answer

    Thank you for your call today and for your questions.

    Here are the products that we discussed:

    1) Rabbit anti-human IgG (H&L) antibody: Ab6715

    https://www.abcam.com/Rabbit-polyclonal-Secondary-Antibody-to-Human-IgG-H-L-ab6715.html

    2) Mouse anti-human IgG (H&L) antibody: Ab34834

    https://www.abcam.com/Mouse-polyclonal-Secondary-Antibody-to-Human-IgG-H-L-ab34834.html

    3) Anti-mouse IgG (H&L) antibody conjugated to AP: Ab7069

    https://www.abcam.com/Mouse-IgG-secondary-antibody-H-L-Pre-Adsorbed-ab7069.html

    This anti-mouse IgG antibody is pre-adsorbed against human IgG, so that it will not bind to the human IgG on the Western blot. It will only bind to the mouse primary antibody.

    I hope this information will be useful, but please let me know if you have any further questions or if there is anything else that we can do for you. Have a nice day.

    Read More

    Abcam Scientific Support

    回复于 Jul 10 2012

    Question

    Yes, if you can please generate me a copy of an MSDS that would be helpful.



    Thanks and regards,

    Read More

    Abcam community

    Verified customer

    Asked on Jun 27 2012

    Answer

    Thank you for your reply.

    I attached the MSDS to this email for your information.

    I hope this ids helpful and wish you good luck with your research.

    Read More

    Abcam Scientific Support

    回复于 Jun 27 2012

    Question

    Hello,



    We received product ab2410 lot #GR74515 Rabbit polyclonal to Human IgG-ChIP Grade. We need an MSDS for our record for any reagents that we receive. Please e-mail me a copy of the MSDS.



    Thanks and regards,







    This email and any attachments contain confidential information. This is a private communication. If you have received this email in error, please notify the sender immediately and do not disclose the contents to another person, use it for another purpose, or store or copy the information in any medium.

    Read More

    Abcam community

    Verified customer

    Asked on Jun 26 2012

    Answer

    Thank you for your inquiry.

    The MSDS PDFsfor our products can be found on the online datasheets.

    If there is not MSDS as in the case of ab2410, this indicates that the product does not contains hazardous substances or only contains so little that a MSDS is not necessary.

    If you still require a MSDS for ab2410, I will be happy to ask the department to generate one for you (which would say, that it is not hazardous in these minute amounts).

    I hope this information is helpful and wish you a good day.

    Read More

    Abcam Scientific Support

    回复于 Jun 26 2012

    Question

    für folgende Antikörper möchte ich eine entsprechende Isotypkontrolle bestellen, um diese bei der Färbung mitzuführen:
    Anti-IL9 antibody (https://www.abcam.com/IL-9-antibody-ab111915.html)
    Anti-IL9R antibody (https://www.abcam.com/IL-9R-antibody-ab106287.html)
    Folgende Isotypkontrollen habe ich auf Ihrer Homepage gefunden:
    Anti-Human IgG antibody (ab2410)
    Anti-Human IgG antibody, prediluted (ab938)
    Sind dies Isotypkontrollen, die für den IL-9 und IL-9R Antikörper empfohlen werden und bei der Etablierung der Färbung mitgeführt wurden?
    Vielen Dank im Voraus.

    Read More

    Abcam community

    Verified customer

    Asked on Apr 25 2012

    Answer

    Vielen Dank für Ihre Nachrichten.

    Leider sind die anti-human IgGs nicht die Kontrollen, die wir Ihnen als Isotypkontrolle für die IL9- und IL9R- Antikörper empfehlen würden. (Damit würden Sie sicher eine Färbung erhalten, die Sie so nicht beabsichtigen).

    Als Isotypkontrolle können wir Ihnen ab27478 oder ab27472 (vorverdünnt=prediluted) empfehlen:

    https://www.abcam.com/Rabbit-IgG-polyclonal-Isotype-Control-ab27478.html (or use the following: https://www.abcam.com/Rabbit-IgG-polyclonal-Isotype-Control-ab27478.html).

    https://www.abcam.com/Rabbit-IgG-polyclonal-Isotype-Control-ab27472.html (or use the following: https://www.abcam.com/Rabbit-IgG-polyclonal-Isotype-Control-ab27472.html).

    Es freut mich zu hören, dass Sie unser Angebot unsere Antikörper ab106287und ab111915an Gefrierschnitten zu testen, annehmen möchten.



    Wie besprochen, können Sie den Gutscheincode zum Kauf jeweils eines weiteren Antikörpers einsetzen, sobald Sie uns ein Abreview für diesen Antikörper eingereicht haben. Der Code wird gültig, sobald Sie uns ein Abreview für diesen Antikörper über den Test in IHC-Fr eingereicht haben. Bitte geben Sie diesen Code auch im Abschnitt “Additional Notes” des Abreviews mit an, so dass wir wissen, dass sich dieses Abreview auf die Gutscheinaktion bezieht. Der Code wird dadurch aktiviert. Bitte kontaktieren Sie bei der nächsten Bestellung unsere Kundendienst mit dem Code und der ursprünglichen Bestellnummer.

    Bitte zögern Sie nicht, sich wieder an uns zu wenden, falls Sie weitere Fragen haben. Wir freuen uns auf Ihr Abreview, egal ob Ihre Ergebnisse positiv oder negativ sind und wünschen Ihnen viel Glück für Ihre Forschung.

    Die Bedingungen dieses Angebotes befinden sich unter dem folgenden Link: https://www.abcam.com/collaborationdiscount

    Read More

    Abcam Scientific Support

    回复于 Apr 25 2012

    Question

    IHC-Fr, injecting human cells into mouse likes to detect human cells only, but not mouse was mouse cross reactivity tested / homology?

    Read More

    Abcam community

    Verified customer

    Asked on Dec 07 2011

    Answer

    Thank you for contacting us. I have heard back from the lab with the following information: This antibody was only tested on human tissues and not on any other species. Therefore, we do not know if it would crossreact with mouse or not. I am sorry to not have more helpful information for you in this regard. Please let me know if you would be looking into other proteins that might show low homology between human and mouse, and I can help you to find a suitable antibody. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Dec 07 2011

    Question

    I'm using this antibody to stain monkey tissue in IHC-P at 1/2000 with pepsin antigen retrieval.  I'm seeing some background though and my negative isotype control shows signal too.

    Read More

    Abcam community

    Verified customer

    Asked on Nov 02 2011

    Answer

    Thank you for contacting us and I'm sorry to hear that you're having some trouble staining with ab2410. We haven't tested this antibody using monkey tissue, only human tissue (tonsil), so we haven't optimized the protocol for monkey. However, I've included some info about the protocol tested for you to try optimizing. Pretreatment enzymatic retrieval: We recommend histozyme treatment (Diagnostic Biosystem cat. #: K 046) for ab2410 for 5 minutes at room temperature. The antibody should be diluted even further if you're seeing background. Try 1/3000 - 1/5000 and dilute your secondary more too. The lab suggests incubating the primary for 30 mins at room temperature. Plus, what are you using for blocking? We'd recommend 5-10% serum from the species your secondary is raised in and incubating that for 1 hr at RT. I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Nov 02 2011

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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