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Microbiology Organism Virus DNA Virus double stranded DNA Virus Human Papillomavirus

Anti-HPV16 L1抗体[CamVir 1] (ab69)

  • Datasheet
  • SDS
Submit a review Q&A (13)References (20)

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Key features and details

  • Mouse monoclonal [CamVir 1] to HPV16 L1
  • Suitable for: WB, IP, IHC-P
  • Reacts with: Human papillomavirus
  • Isotype: IgG2a

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概述

  • 产品名称

    Anti-HPV16 L1抗体[CamVir 1]
    参阅全部 HPV16 L1 一抗
  • 描述

    小鼠单克隆抗体[CamVir 1] to HPV16 L1
  • 宿主

    Mouse
  • 特异性

    The antibody reacts with a 56 kDa protein in cells infected with L1-vaccinia virus, the protein being present in a predominantly nuclear location. The antibody reacts very strongly with biopsy specimins containing HPV-16 or -33; very weak reactions were occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. Cross-reacts with HPV37.
  • 经测试应用

    适用于: WB, IP, IHC-Pmore details
  • 种属反应性

    与反应: Human papillomavirus
  • 免疫原

    Fusion protein corresponding to Human papillomavirus HPV16 L1. A b galactosidase-L1 fusion protein purified by PAGE.

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    Phosphate buffered saline
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 克隆

    单克隆
  • 克隆编号

    CamVir 1
  • 骨髓瘤

    NS0
  • 同种型

    IgG2a
  • 轻链类型

    unknown
  • 研究领域

    • Microbiology
    • Organism
    • Virus
    • DNA Virus
    • double stranded DNA Virus
    • Human Papillomavirus
    • Cancer
    • Oncoproteins/suppressors
    • Viral proteins
    • HPV
    • Microbiology
    • Protein
    • Viral Protein

相关产品

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)
  • Recombinant Protein

    • Recombinant HPV16 L1 protein (ab119880)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab69于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
Use at an assay dependent concentration. Predicted molecular weight: 56 kDa.
IP
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.
说明
WB
Use at an assay dependent concentration. Predicted molecular weight: 56 kDa.
IP
Use at an assay dependent concentration.
IHC-P
Use at an assay dependent concentration.

靶标

  • 相关性

    L1 is a major capsid protein of type 16 human papilloma virus. Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies.
  • 细胞定位

    Virion. Host Nucleus.
  • 数据库链接

    • Entrez Gene: 1489082 Human papillomavirus
    • SwissProt: P03101 Human papillomavirus
    • 别名

      • HPV-16 antibody
      • HPV-16 capsid antibody
      • HPV16 capsid protein antibody
      • HPV16 L1 antibody
      • HPV16 major capsid protein L1 antibody
      • Human papillomavirus type 16 L1 antibody
      • Human papillomavirus type 16 major capsid protein L1 antibody
      • L1 antibody
      • Major capsid L1 protein antibody
      • Major capsid protein antibody
      • Major capsid protein L1 antibody
      see all

    实验方案

    • Immunoprecipitation protocols
    • Immunohistochemistry protocols
    • Western blot protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (20)

    发表研究结果有使用 ab69?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab69 被引用在 20 文献中.

    • Karimi H  et al. Combination therapy using human papillomavirus L1/E6/E7 genes and archaeosome: a nanovaccine confer immuneadjuvanting effects to fight cervical cancer. Sci Rep 10:5787 (2020). PubMed: 32238821
    • Mboumba Bouassa RS  et al. Serum and cervicovaginal IgG immune responses against a7 and a9 HPV in non-vaccinated women at risk for cervical cancer: Implication for catch-up prophylactic HPV vaccination. PLoS One 15:e0233084 (2020). PubMed: 32421735
    • Ðuraševic S  et al. The Effects of Meldonium on the Renal Acute Ischemia/Reperfusion Injury in Rats. Int J Mol Sci 20:N/A (2019). PubMed: 31731785
    • Wu X  et al. Induction of neutralizing antibodies by human papillomavirus vaccine generated in mammalian cells. Antib Ther 2:45-53 (2019). PubMed: 33928221
    • Xv Z  et al. Effective Neutralizing Antibody Produced in Mice Directly Immunized with Integrated Pichia pastoris Expressing HPV16L1 Protein. Viral Immunol 32:308-317 (2019). PubMed: 31381497
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-10 of 13 Abreviews or Q&A

    Question

    Thank you very much for the information.
    I am however looking for the binding site of your camVir1 antibody. That is against HPV16 L1. Do you have a paper on that?
    Thanking you for your help

    Read More

    Abcam community

    Verified customer

    Asked on Feb 21 2013

    Answer

    Thank you for contacting us.

    Unfortunately, we do not have any other information about the binding site, I am afraid!. The CamVir1 clone is a published clone, please check the literature if anybody else have published any more details about the epitope.

    I hope this information is nevertheless helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Feb 21 2013

    Question

    Product code: 69
    Inquiry: Hi, Which epitope on L1 does camvir1 bind to? Thanks Inga

    Read More

    Abcam community

    Verified customer

    Asked on Feb 21 2013

    Answer

    Thank you for contacting us.

    The exact epitope sequence has been mapped. The immunogen is a gel-purified HPV-18 E6-b galactosidase fusion protein.

    Please check the link below of original publication;

    http://vir.sgmjournals.org/content/68/5/1351.full.pdf

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Feb 21 2013

    Question

    What is the epitope of antibody ab69?

    Read More

    Abcam community

    Verified customer

    Asked on Sep 12 2012

    Answer

    Thank you for contacting us.

    Please find attached the requested paper.

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Use our products? Submit an Abreview. Earn rewards!
    https://www.abcam.com/abreviews

    Read More

    Abcam Scientific Support

    回复于 Sep 12 2012

    Question

    Dear technical team,

    Our customer is going to purchase ab69 and she would like to know if it has cross-reactivity to other HPV types except type 16.
    Please let me know.

    Best regards

    Read More

    Abcam community

    Verified customer

    Asked on Aug 17 2012

    Answer

    Thank you for contacting us.

    The anti-HPV16 L1 antibody [CamVir 1] (ab69) has shown some cross reactivity with other HPV types other than 16.The antibody reacts very strongly with biopsy specimens containing HPV-16 or -33, whilstvery weak reactionshave occasionally observed with biopsy specimens or smears containing HPV-6 or HPV-11. There has also been cross reactivity observed with HPV37.

    I hope this information has been of help. If you have any other questions, please do not hesitate to ask.

    Read More

    Abcam Scientific Support

    回复于 Aug 17 2012

    Question

    Hola de nuevo Abcam:
    Uno de nuestros clientes adquirió estos 3 anticuerpos con nosotros, ellos los alicuotaron y almacenaron a -20°C, ahora que tratan de usarlos ninguno de los tres funciona, nos podrán ayudar, aún están dentro de los 6 meses de abpromise?
    AB10419 LOTE XXXXXXXX
    AB69 LOTE XXXXXXXXXX
    AB10505 LOTE XXXXXXXXX
    Muchas Gracias.¡

    Read More

    Abcam community

    Verified customer

    Asked on Mar 27 2012

    Answer

    Gracias por contactarnos de nuevo.

    ¿Podrías por favor indicarme el número de pedido en el que se enviaron los anticuerpos? ¿En qué estado se recibieron? ¿Nada más recibirlos se alicuotaron y guardaron a -20C?

    ¿En qué aplicación y especies se están usando?

    Te agradezco que nos facilites estos detalles para poder entender mejor qué ha podido ocurrir para que ninguno de los tres anticuerpos funcione.

    Gracias por la colaboración. Quedo a la espera de tu respuesta.

    Read More

    Abcam Scientific Support

    回复于 Mar 27 2012

    Question

    Thank you what is the status of our order?

    Read More

    Abcam community

    Verified customer

    Asked on Jan 26 2012

    Answer

    Unfortunately shipment of this order is being held up by our accounts team.

    Our accounting department can be contacted by email at mailto:us.credits@abcam.com or by telephone using the information at the Contact Us link in the top right corner of our website. Please refer to theorder reference numberin any correspondence with our accounting department.

    I hope this is helpful. Please contact me again with any technical questions you may have.

    Read More

    Abcam Scientific Support

    回复于 Jan 26 2012

    Question

    I purchased your mouse anti-HPV 16 L1 ab a while back. I am using the ab for ELISA purposes (to test levels of HPV specific IgG). I am trying to figure out appropriate standards for my ELISA. At first, I was thinking that I might coat a plate with anti-mouse IgG, titrate purified normal mouse IgG, and probe with a goat anti-mouse IgG-HRP Ab. But I wonder, if I coat with anti-mouse IgG, could I titrate with the Ab69 and pick up a signal after probing with goat anti-mouse IgG-HRP. I'm thinking the answer is no, but wanted to check. Could you help me figure out appropriate standards for using this antibody in ELISA format?

    Read More

    Abcam community

    Verified customer

    Asked on Jan 19 2012

    Answer

    Thank you for contacting us.


    If I understand you correctly. The anti-mouse IgG would recognize your purified normal mouse IgG or it would recognize Ab69. These, in turn, would be recognized by goat anti-mouse HRP. However if you are to use ab69 against HPV in mouse tissues your detection antibody (goat anti-mouse IgG-HRP) should IgG2a specific,as it may recognize both ab69 and the Fc receptors in the tissue thereby creating a false positive.

    It seems that youare proposing a sandwich ELISA. These can be difficult to optimize. The antibodies must be detecting different epitopes of the antigen so they do not inferfere with the other antibody binding. We are unable to guarantee our antibodies in sandwich ELISA unless they have been specifically tested in that application.

    If ab69 is your detection


    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Read More

    Abcam Scientific Support

    回复于 Jan 19 2012

    Question

    To Whom It May Concern:   I am requesting an MSDS (Material Safety Data Sheet) for a product used by a client of mine, Thunder Bay Regional Research.  The products are as follows:   -HPV16 L1 (product code: ab69) -HPV16 E2 (product code: ab17185) -mouse monoclonal to CD11C (BU15) (product code: ab11029) -Carbonic anhydrase 9 (product code: AB47011) -ChIP Kit (product code: AB500) -mouse monoclonal to HPV16 E6 and HPV 18 E6 (C1P5) (product code: ab70)   Are these products exempt from having an msds?  

    Read More

    Abcam community

    Verified customer

    Asked on Oct 19 2011

    Answer

    Thank you for contacting Abcam. I have attached the MSDS for all except ab500, ChIP kit. I am still waiting for the laboratory to get back to me on that one and I will send it on as soon as I get it. If there is anything else I can do, please let me know.

    Read More

    Abcam Scientific Support

    回复于 Oct 19 2011

    Question

    Dear technical team,   Our customer would like to know more information about immunogen of ab69 and ab30908.   If you have information of amino acid sequence, please let me know.   Thank you in advance.

    Read More

    Abcam community

    Verified customer

    Asked on Sep 30 2011

    Answer

    Thank you for your inquiry. Both Anti-HPV16 L1 recognise HPV Type 16, L1 (major capsid protein). Unfortunately, we do not currently have more information about the epitopes for those monoclonal antibodies. We will update the on-line datasheet for this product as soon as we receive additional data. We apologize for any inconvenience this may cause.

    Read More

    Abcam Scientific Support

    回复于 Sep 30 2011

    Question

    We routinely buy antibodies from Abcam, so I was wondering if you could send us a small amount of the ab69 HPV16-L1 (CamVir 1) antibody to test before we purchase a larger amount.

    Read More

    Abcam community

    Verified customer

    Asked on Jul 06 2005

    Answer

    Thank you for your email. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you decide to test an antibody in an application for which we do not have any information, please let us know how you get on and in return we will award you 100 points with the Abcam Loyalty Scheme which can be redeemed on a number of rewards. If you have any additional questions, please contact us again.

    Read More

    Abcam Scientific Support

    回复于 Jul 06 2005

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