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Epigenetics and Nuclear Signaling DNA / RNA RNA Processing

Anti-hnRNP A2B1抗体[DP3B3] (ab6102)

  • Datasheet
  • SDS
Reviews (7)Q&A (5)References (43)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)

Key features and details

  • Mouse monoclonal [DP3B3] to hnRNP A2B1
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG2a

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概述

  • 产品名称

    Anti-hnRNP A2B1抗体[DP3B3]
    参阅全部 hnRNP A2B1 一抗
  • 描述

    小鼠单克隆抗体[DP3B3] to hnRNP A2B1
  • 宿主

    Mouse
  • 经测试应用

    适用于: IHC-Pmore details
  • 种属反应性

    与反应: Human
  • 免疫原

    Bacterially expressed His-hnRNPA2 fusion protein (Human).

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液

    Preservative: 0.1% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • 纯度

    Protein A purified
  • 纯化说明

    Purified from supernatant.
  • 克隆

    单克隆
  • 克隆编号

    DP3B3
  • 骨髓瘤

    Sp2/0
  • 同种型

    IgG2a
  • 研究领域

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • RNA Processing
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • RNA Processing
    • Other

相关产品

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG2a, kappa monoclonal [MG2a-53] - Isotype control (ab18415)
  • Recombinant Protein

    • Recombinant Human hnRNP A2B1 protein (ab224866)

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab6102于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
IHC-P (1)
Use a concentration of 1 µg/ml.
说明
IHC-P
Use a concentration of 1 µg/ml.

靶标

  • 功能

    Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.
  • 序列相似性

    Contains 2 RRM (RNA recognition motif) domains.
  • 细胞定位

    Nucleus > nucleoplasm. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.
  • Target information above from: UniProt accession P22626 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 3181 Human
    • Omim: 600124 Human
    • SwissProt: P22626 Human
    • Unigene: 487774 Human
    • 别名

      • Heterogeneous nuclear ribonucleoprotein A2 antibody
      • Heterogeneous nuclear ribonucleoprotein A2/B1 antibody
      • Heterogeneous nuclear ribonucleoprotein B1 antibody
      • Heterogeneous nuclear ribonucleoproteins A2/B1 antibody
      • hnRNP A2 / hnRNP B1 antibody
      • hnRNP A2 antibody
      • hnRNP A2/B1 antibody
      • hnRNP B1 antibody
      • hnRNP-A2 antibody
      • hnRNP-B1 antibody
      • hnRNPA2 antibody
      • Hnrnpa2b1 antibody
      • hnRNPB1 antibody
      • HNRPA2 antibody
      • HNRPA2B1 antibody
      • HNRPB1 antibody
      • Nuclear ribonucleoprotein particle A2 protein antibody
      • RNP A2 antibody
      • RNP B1 antibody
      • RNP-A2 antibody
      • RNP-B1 antibody
      • RNPA2 antibody
      • RNPB1 antibody
      • ROA2_HUMAN antibody
      • SNRPB1 antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)
      ab6102 (1µg/ml) staining hnRNP A2B1 in human liver.
      Sections were stained using an automated system (DAKO Autostainer Plus), at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers citrate pH6.1 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP A2B1 antibody [DP3B3] (ab6102)
      ab6102 (1µg/ml) staining hnRNP A2B1 in human caecum, using an automated system (DAKO Autostainer Plus). Using this protocol there is strong nuclear staining in the mucosal epithelium.
      Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

    实验方案

    • Immunohistochemistry protocols

    Click here to view the general protocols

    数据表及文件

    • SDS download

    • Datasheet download

      Download

    文献 (43)

    发表研究结果有使用 ab6102?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab6102 被引用在 43 文献中.

    • Zhang Y  et al. Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1. J Exp Clin Cancer Res 39:141 (2020). PubMed: 32698890
    • Yang Y  et al. Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer Lett 475:43-52 (2020). PubMed: 32006618
    • Oh JG  et al. Analysis of extracellular vesicle miRNA profiles in heart failure. J Cell Mol Med 24:7214-7227 (2020). PubMed: 32485073
    • Coppola A  et al. Anti-Inflammatory Action of Heterogeneous Nuclear Ribonucleoprotein A2/B1 in Patients with Autoimmune Endocrine Disorders. J Clin Med 9:N/A (2019). PubMed: 31861546
    • Mori S  et al. Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease. Neuropathology 39:358-367 (2019). PubMed: 31599037
    View all Publications for this product

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-hnRNP A2B1 antibody [DP3B3]

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Human Tissue sections (Human Bladder Cancer)
    Specification
    Human Bladder Cancer
    Fixative
    Formaldehyde
    Antigen retrieval step
    Heat mediated
    Permeabilization
    No
    Read More

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