抗丙型肝炎病毒抗体(ab1033)

Submit a review Q&A (3)References (7)

Key features and details

  • Rabbit polyclonal to Hepatitis C Virus
  • Suitable for: WB
  • Reacts with: Hepatitis C virus
  • Isotype: unknown

概述

  • 产品名称

    抗丙型肝炎病毒抗体
    参阅全部 Hepatitis C Virus 一抗

  • 描述

    兔多克隆抗体to丙型肝炎病毒

  • 宿主

    Rabbit

  • 特异性

    This antibody recognizes the core protein C1 of Hepatitis C Virus.

  • 经测试应用

    适用于: WBmore details

  • 种属反应性

    与反应: Hepatitis C virus

  • 免疫原

    Peptide corresponding to amino acids 9-21 of Hepatitis C Virus (HCV) core protein C1.

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 存储溶液

    pH: 7.4
    Preservative: 0.05% Sodium azide
  • Concentration information loading...

  • 纯度

    Immunogen affinity purified

  • 克隆

    多克隆

  • 同种型

    unknown

  • 轻链类型

    unknown

  • 研究领域

应用

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab1033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
1/500 - 1/1000.
说明
WB
1/500 - 1/1000.

靶标

  • 相关性

    Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha.

  • 细胞定位

    Virus surface

  • 数据库链接

    • 别名

      • Genome polyprotein antibody
      • HCV antibody
      • Hepatitis C virus polyprotein antibody

    文献 (7)

    发表研究结果有使用 ab1033？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab1033 被引用在 7 文献中.

    • Mittal N  et al. Versican is crucial for the initiation of cardiovascular lumen development in medaka (Oryzias latipes). Sci Rep 9:9475 (2019). PubMed: 31263118
    • Hulin A  et al. Maturation of heart valve cell populations during postnatal remodeling. Development 146:N/A (2019). PubMed: 30796046
    • Joost S  et al. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing. Cell Rep 25:585-597.e7 (2018). PubMed: 30332640
    • Meier-Abt F  et al. Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. Breast Cancer Res 15:R36 (2013). IHC ; Mouse . PubMed: 23621987
    • Hattori N  et al. Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis. J Biol Chem 286:34298-310 (2011). PubMed: 21828051
    • Velasco J  et al. Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor ß1 (TGFß1) signaling. J Biol Chem 286:26016-27 (2011). PubMed: 21566131
    • Yuk CS  et al. Development and evaluation of a protein microarray chip for diagnosis of hepatitis C virus. Biotechnol Lett 26:1563-8 (2004). PubMed: 15604797

    客户评价及客户问答

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    Question

    I am searching for an antibody to Hepatitis C strain 2a for use with Western blotting. I see that you have several HCV antibodies but could only find information regarding which strain they were raised against for a few. An HCV core protein antibody may be suitable from another strain if it can be used in Western blotting assays but one specifically raised against strain 2a would be best. I would appreciate any further information you might be able to provide and thank you in advance for your time and consideration.

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    Answer

    Thank you for your enquiry. I looked up some Hepatitis C Virus antibodies that may be of interest to you and the information is listed below. It does not appear that we have one that is specific for strain 2a or has even bee tested for reactivity with that strain. Please contact us again if you have any additional questions. Ab20773 - Goat polyclonal to Hepatitis C Virus NS5: Immunogen used was recombinant NS5 a&b genotype 1a (100% of a and 70% of b). This antibody has not been tested for reactivity to genotype 2a. Ab1035 - Rabbit polyclonal to Hepatitis C Virus: Immunogen used was a peptide corresponding to amino acids 33-43 of Hepatitis C Virus (HCV) core protein C3. Ab1033 - Rabbit polyclonal to Hepatitis C Virus: Immunogen used was a peptide corresponding to amino acids 9-21 of Hepatitis C Virus (HCV) core protein C1. For ab1035 and ab1033, strain 2a hasn't been tested, but the understanding is that the sequences derived from core proteins C1 and C3 which were used for immunization are well conserved in the different strains of Hepatitis C virus. Therefore, it is likely that these antibodies will react with Hepatitis C strain 2a. Ab18662 - Mouse monoclonal [24-8 ] to Hepatitis C Virus: Immunogen used was a highly antigenic polypeptide consisting of essential sequences of at least 60 residues in length, which were selected from genes encoding the NS-3 region of Chinese HCV strains. This antibody is not hepatitis C virus[HCV] strain specific, and will recognize the NS3 of HCV strains. If the NS3 variation has been observed in this strain, it may cause the weaker/or non reaction when using this antibody, in the case of the variation is matched the epitope region or interfered the Antibody-Antigen binding-reaction site/sequences. Ab27791 - Goat polyclonal to Hepatitis C Virus: Immunogen used was recombinant chimeric HCV polyprotein (60 kDa). This antibody product will react with various HCV, and the reaction is not HCV strain specific.

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    Question

    Can you tell me the HCV strain used to generate the core antigen? Sincerely,

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    Answer

    The HCV strain is subtype 1a.

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    Question

    We are looking for an antibody (monoclonal or polyclonal in nature) that will specifically bind to HCV core protein in western blots. Can you tell me whether this product or ab1033 is suitable for this prupose, and will it be possible to obtain a small aliquot so we can confirm that this antibody works in our hands?

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    Answer

    Thank you for your enquiry. Ab1033 - Rabbit polyclonal to Hepatitis C Virus - does recognize the core protein C1 of Hepatitis C Virus. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you decide to test an antibody in an application for which we do not have any information, please let us know how you get on and in return we will forward a GBP10/ USD15/ EUR15 Amazon gift voucher.

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