抗乙型肝炎病毒X antigen抗体(ab39716)
Key features and details
- Rabbit polyclonal to Hepatitis B Virus X antigen
- Suitable for: ELISA, WB, IP
- Reacts with: Hepatitis B virus
- Isotype: IgG
概述
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产品名称
抗乙型肝炎病毒X antigen抗体
参阅全部 Hepatitis B Virus X antigen 一抗 -
描述
兔多克隆抗体to乙型肝炎病毒X antigen -
宿主
Rabbit -
特异性
The amino acid sequence of the recombinant human Hepatitis B Protein X is 100% homologous to the amino acid sequence of the natural Hepatitis B Protein X. -
经测试应用
适用于: ELISA, WB, IPmore details -
种属反应性
与反应: Hepatitis B virus -
免疫原
Recombinant full length protein corresponding to Hepatitis B virus Hepatitis B Virus X antigen aa 1-154.
Database link: P12936 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Constituents: 0.58% Sodium chloride, 0.134% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab39716于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 17 kDa.
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IP |
Use at an assay dependent concentration.
|
说明 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 17 kDa. |
IP
Use at an assay dependent concentration. |
靶标
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相关性
Hepatitis B virus X protein (HBx) is a 17 kD transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcinogenesis. HBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. The communication between HBx and general transcription factor TFIIB is also one of the mechanisms which account for its transcriptional transactivation. HBx decreased the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidylinositol 3'-kinase/AKT and HBx decreased the expression of PTEN in HBx-transfected cells. The etiology of hepatocellular carcinoma (HCC) is involved with hepatitis B virus (HBV) infection and HBx in particular plays a role in the development of HBV-related HCC. The persistence of HBx is important to the pathogenesis of early HCC and HBx expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC. -
数据库链接
- SwissProt: O91531 Hepatitis B virus
- SwissProt: Q4R1S1 Hepatitis B virus
- SwissProt: Q91C38 Hepatitis B virus
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别名
- HBV X antigen antibody
- HBx antibody
- HBxAg antibody
数据表及文件
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Datasheet download
文献 (27)
ab39716 被引用在 27 文献中.
- Li J et al. lncNBAT1/APOBEC3A is a mediator of HBX-induced chemoresistance in diffuse large B cell lymphoma cells. Mol Ther Nucleic Acids 27:1064-1077 (2022). PubMed: 35228900
- Wei XF et al. Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labeling. iScience 25:104416 (2022). PubMed: 35663023
- Oda C et al. HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochem Biophys Rep 32:101352 (2022). PubMed: 36160029
- Niu Y et al. Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis. J Clin Transl Hepatol 9:466-476 (2021). PubMed: 34447675
- Ni Z et al. Transcriptomic identification of HBx-associated hub genes in hepatocellular carcinoma. PeerJ 9:e12697 (2021). PubMed: 35036167