Key features and details
- Rabbit polyclonal to HDAC7
- Suitable for: IHC-Fr, WB, IP
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 1% BSA
Concentration information loading...
纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab1441 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use a concentration of 30 µg/ml.|
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 102.9 kDa.|
|IP||Use a concentration of 20 - 40 µg/ml.|
功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
序列相似性Belongs to the histone deacetylase family. HD type 2 subfamily.
结构域The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
翻译后修饰May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
细胞定位Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and may be due to its phosphorylation.
- Information by UniProt
- DKFZP586J0917 antibody
- FLJ99588 antibody
- HD 7a antibody
ab1441 被引用在 2 文献中.
- Zhou B et al. Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear ß-catenin translocation. Arterioscler Thromb Vasc Biol 31:2676-84 (2011). PubMed: 21836063
- Chang S et al. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell 126:321-34 (2006). ChIP ; Human . PubMed: 16873063