Anti-HBEGF/DTR抗体[MM0324-3R44] (ab89241)
Key features and details
- Mouse monoclonal [MM0324-3R44] to HBEGF/DTR
- Suitable for: Neutralising, WB
- Reacts with: Human
- Isotype: IgG2
概述
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产品名称
Anti-HBEGF/DTR抗体[MM0324-3R44]
参阅全部 HBEGF/DTR 一抗 -
描述
小鼠单克隆抗体[MM0324-3R44] to HBEGF/DTR -
宿主
Mouse -
经测试应用
适用于: Neutralising, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein corresponding to Human HBEGF/DTR.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. -
克隆
单克隆 -
克隆编号
MM0324-3R44 -
同种型
IgG2 -
研究领域
相关产品
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89241于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Neutralising |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
|
说明 |
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Neutralising
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
靶标
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功能
May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. -
序列相似性
Contains 1 EGF-like domain. -
翻译后修饰
Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-linked glycan attachment sites were determined by Edman degradation, O-glycanase digest suggests mucin-type glycosylation (done in HB-EGF purified from histiocytic lymphoma cell line U-937). -
细胞定位
Cell membrane and Secreted > extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor. - Information by UniProt
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数据库链接
- Entrez Gene: 1839 Human
- Omim: 126150 Human
- SwissProt: Q99075 Human
- Unigene: 799 Human
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别名
- diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody
- diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody
- Diphtheria toxin receptor antibody
see all
数据表及文件
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Datasheet download
文献 (2)
ab89241 被引用在 2 文献中.
- Luo P et al. s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide. Cell Res 30:779-793 (2020). PubMed: 32296111
- Liu J et al. CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17. Int J Biol Sci 15:493-506 (2019). PubMed: 30745837