Anti-Haptoglobin抗体[HG-36] (ab13429)
Key features and details
- Mouse monoclonal [HG-36] to Haptoglobin
- Suitable for: ELISA, Dot blot, ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-Haptoglobin抗体[HG-36]
参阅全部 Haptoglobin 一抗 -
描述
小鼠单克隆抗体[HG-36] to Haptoglobin -
宿主
Mouse -
经测试应用
适用于: ELISA, Dot blot, ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Full length native protein (Purified haptoglobin types 1-1, 2-1, and 2-2 from pooled human plasma).
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常规说明
This product was changed from ascites to tissue culture supernatant on 17 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.098% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Proprietary Purification -
纯化说明
Purified from hybridoma cell culture -
克隆
单克隆 -
克隆编号
HG-36 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab13429于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ELISA |
Use at an assay dependent concentration.
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Dot blot |
Use at an assay dependent concentration.
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|
ICC/IF | (2) |
Use at an assay dependent concentration.
|
WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa.
|
IHC-P | (4) |
Use at an assay dependent concentration.
See Abreview. |
说明 |
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ELISA
Use at an assay dependent concentration. |
Dot blot
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa. |
IHC-P
Use at an assay dependent concentration. See Abreview. |
靶标
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功能
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. -
组织特异性
Expressed by the liver and secreted in plasma. -
疾病相关
Anhaptoglobinemia -
序列相似性
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 3240 Human
- Omim: 140100 Human
- SwissProt: P00738 Human
- Unigene: 513711 Human
- Unigene: 702099 Human
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别名
- Binding peptide antibody
- BP antibody
- Haptoglobin alpha chain antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (18)
ab13429 被引用在 18 文献中.
- Gunzer S et al. Hypertransaminasemia and liver fibrosis associated with haptoglobin retention and anhaptoglobinemia in a paediatric patient. Liver Int 41:2427-2432 (2021). PubMed: 34358398
- Calvo E et al. Why Does COVID-19 Affect Patients with Spinal Cord Injury Milder? A Case-Control Study: Results from Two Observational Cohorts. J Pers Med 10:N/A (2020). PubMed: 33096722
- Cao J et al. Identification of an activation-related protein in B cells in the ABO incompatible condition. Exp Ther Med 19:741-747 (2020). PubMed: 31897108
- Arya R et al. Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response. Proteomics Clin Appl 14:e1900062 (2020). PubMed: 31532894
- Gallo JRB et al. Skin Protein Profile after Major Weight Loss and Its Role in Body Contouring Surgery. Plast Reconstr Surg Glob Open 7:e2339 (2019). PubMed: 31592376