GSK-J4,histone demethylase JMJD3/UTX抑制剂(ab144395)
Key features and details
- Cell permeable histone demethylase JMJD3/UTX inhibitor
- CAS Number: 1373423-53-0
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
GSK-J4,histone demethylase JMJD3/UTX抑制剂 -
描述
Cell permeable histone demethylase JMJD3/UTX抑制剂 -
别名
- Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate
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纯度
> 98% -
CAS编号
1373423-53-0 -
化学结构
性能
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化学名称
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester -
分子量
417.51 -
分子式
C24H27N5O2 -
PubChem识别号
71729974 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in DMSO to 100 mM and in ethanol to 100mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4.Cl -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (6)
ab144395 被引用在 6 文献中.
- Gao Y et al. JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation. Environ Toxicol 38:754-769 (2023). PubMed: 36537648
- Gao Y et al. H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury. Cell Death Discov 8:475 (2022). PubMed: 36456564
- Sun J et al. microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-?B signaling pathway. Stem Cell Res Ther 12:14 (2021). PubMed: 33413595
- Yamada T et al. Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells. J Immunol 202:1088-1098 (2019). PubMed: 30626691
- Zhang YX et al. The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory. Neuropharmacology 141:113-125 (2018). PubMed: 30165076
- Watarai H et al. Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin. Anticancer Res 36:6083-6092 (2016). PubMed: 27793936