Anti-GABARAP抗体(ab1398)
Key features and details
- Rabbit polyclonal to GABARAP
- Suitable for: ELISA, WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-GABARAP抗体
参阅全部 GABARAP 一抗 -
描述
兔多克隆抗体to GABARAP -
宿主
Rabbit -
特异性
This antibody recognizes human GABARAP (14 kD). -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide:
RSEGEKIRKKYPDRVPV
, corresponding to amino acids 15-31 of Human GABARAP. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide -
Concentration information loading... -
纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
|
|
| WB | (1) |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
ELISA
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. -
组织特异性
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. -
序列相似性
Belongs to the ATG8 family. -
翻译后修饰
The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II. -
细胞定位
Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). - Information by UniProt
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数据库链接
- Entrez Gene: 11337 Human
- Entrez Gene: 56486 Mouse
- Omim: 605125 Human
- SwissProt: O95166 Human
- SwissProt: Q9DCD6 Mouse
- Unigene: 647421 Human
- Unigene: 272460 Mouse
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别名
- ATG8A antibody
- FLC 3B antibody
- FLC3B antibody
see all
数据表及文件
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Datasheet download
文献 (3)
ab1398 被引用在 3 文献中.
- Li L et al. Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits. Mol Med Rep 16:215-223 (2017). WB ; Rabbit . PubMed: 28534953
- Ning HJ et al. Propofol reduces hypoxia-induced autophagic cell death through downregulating HIF 1a in alveolar epithelial type II cells of rats. Mol Med Rep 16:1509-1515 (2017). PubMed: 28586054
- Belichenko PV et al. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol 512:453-66 (2009). Mouse . PubMed: 19034952
