Anti-FOXP2抗体- C-terminal (ab1307)
Key features and details
- Goat polyclonal to FOXP2 - C-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FOXP2抗体- C-terminal
参阅全部 FOXP2 一抗 -
描述
山羊多克隆抗体to FOXP2 - C-terminal -
宿主
Goat -
特异性
This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1). -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Dog, Pig, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla
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免疫原
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阳性对照
- WB: Human cerebellum cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.05% Tris, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (1) |
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 79.9 kDa).
1 hour primary incubation is recommended for this product. |
| 说明 |
|---|
|
WB
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 79.9 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. -
组织特异性
Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. -
疾病相关
Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.
Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2). -
序列相似性
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain. -
发展阶段
Expressed in the brain at 15 and 22 weeks of gestation, with a pattern of strong cortical, basal ganglia, thalamic and cerebellar expression. Highly expressed in the head and tail of nucleus caudatus and putamen. Restricted expression within the globus pallidus, with high levels in the pars interna, which provides the principal source of output from the basal ganglia to the nucleus centrum medianum thalami (CM) and the major motor relay nuclei of the thalamus. In the thalamus, present in the CM and nucleus medialis dorsalis thalami. Lower levels are observed in the nuclei anterior thalami, dorsal and ventral, and the nucleus parafascicularis thalami. Expressed in the ventrobasal complex comprising the nucleus ventralis posterior lateralis/medialis. The ventral tier of the thalamus exhibits strong expression, including nuclei ventralis anterior, lateralis and posterior lateralis pars oralis. Also expressed in the nucleus subthalamicus bilaterally and in the nucleus ruber. -
结构域
The leucine-zipper is required for dimerization and transcriptional repression. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 449627 Chimpanzee
- Entrez Gene: 101150977 Gorilla
- Entrez Gene: 93986 Human
- Entrez Gene: 114142 Mouse
- Entrez Gene: 500037 Rat
- Entrez Gene: 613237 Rhesus monkey
- Entrez Gene: 734154 Xenopus laevis
- Omim: 605317 Human
see all -
别名
- CAG repeat protein 44 antibody
- CAGH44 antibody
- DKFZp686H1726 antibody
see all
图片
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Western blot - Anti-FOXP2 antibody - C-terminal (ab1307)Anti-FOXP2 antibody - C-terminal (ab1307) at 2 µg/ml + Human cerebellum whole cell lysate
Developed using the ECL technique.
Predicted band size: 79.9 kDa
实验方案
数据表及文件
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Datasheet download
文献 (24)
ab1307 被引用在 24 文献中.
- Xiao L et al. Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird. Nat Commun 12:2617 (2021). PubMed: 33976169
- Pourchet O et al. Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements. Cell Rep 34:108654 (2021). PubMed: 33472083
- Lee Y et al. Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice. Mol Cells 43:360-372 (2020). PubMed: 31940718
- Kanemoto M et al. Stress-Related Neuronal Clusters in Sublenticular Extended Amygdala of Basal Forebrain Show Individual Differences of Positions. Front Neural Circuits 14:29 (2020). PubMed: 32547372
- Zhang J et al. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature 588:459-465 (2020). PubMed: 32866962
