Key features and details
- Rabbit polyclonal to FKBP51
- Suitable for: WB
- Reacts with: Mouse, Rat, Hamster, Dog, Human, Xenopus laevis, Non human primates
- Isotype: IgG
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, PBS
Concentration information loading...
纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab2901 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa. By Western blot, this antibody detects an ~51 kDa protein representing FKBP 51 in HeLa cell lysate. By Western blot this antibody also detects FKBP 51 in whole tissue extracts from rat kidney and rat and mouse testes.|
功能Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
组织特异性Widely expressed, enriched in testis compared to other tissues.
序列相似性Contains 2 PPIase FKBP-type domains.
Contains 3 TPR repeats.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
- Information by UniProt
- 51 kDa FK506 binding protein 5 antibody
- 51 kDa FK506 binding protein antibody
- 51 kDa FK506-binding protein antibody
All lanes : Anti-FKBP51 antibody (ab2901) at 2 µg/ml
Lane 1 : K562 (human chronic myelogenous leukemia cell line from bone marrow) nuclear enriched extract
Lane 2 : HepG2 (human liver hepatocellular carcinoma cell line) nuclear enriched extract
Lane 3 : PC-3 (human prostate adenocarcinoma cell line) nuclear enriched extract
Lane 4 : MCF7 (human breast adenocarcinoma cell line) nuclear enriched extract
Lysates/proteins at 30 µg per lane.
All lanes : Goat anti-Rabbit IgG (H+L) at 1/2500 dilution
Approximately 51 and 45 kDa bands corresponding to FKBP51 were observed across cell lines tested
Anti-FKBP51 antibody (ab2901) at 2 µg/ml + HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
ab2901 被引用在 15 文献中.
- Lu A et al. Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy. Sci Rep 10:7075 (2020). PubMed: 32341395
- Hadamitzky M et al. Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats. Int J Neuropsychopharmacol 21:592-602 (2018). PubMed: 29462337
- Criado-Marrero M et al. Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear. Learn Mem 24:145-152 (2017). PubMed: 28298552
- Li K et al. ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. Sci Rep 7:42759 (2017). PubMed: 28287091
- Herring A et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement 12:1273-1287 (2016). PubMed: 27327541