Anti-FKBP51抗体(ab2901)
Key features and details
- Rabbit polyclonal to FKBP51
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FKBP51抗体
参阅全部 FKBP51 一抗 -
描述
兔多克隆抗体to FKBP51 -
宿主
Rabbit -
Tested Applications & Species
Application Species WB Human -
免疫原
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab2901 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
应用 | Species |
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WB |
Human
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应用 | Ab评论 | 说明 |
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WB | (2) |
Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa. By Western blot, this antibody detects an ~51 kDa protein representing FKBP 51 in HeLa cell lysate.
By Western blot this antibody also detects FKBP 51 in whole tissue extracts from rat kidney and rat and mouse testes.
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说明 |
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WB
Use a concentration of 1 µg/ml. Detects a band of approximately 51 kDa. By Western blot, this antibody detects an ~51 kDa protein representing FKBP 51 in HeLa cell lysate. By Western blot this antibody also detects FKBP 51 in whole tissue extracts from rat kidney and rat and mouse testes. |
靶标
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功能
Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. -
组织特异性
Widely expressed, enriched in testis compared to other tissues. -
序列相似性
Contains 2 PPIase FKBP-type domains.
Contains 3 TPR repeats. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Cytoplasm. Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 2289 Human
- Omim: 602623 Human
- SwissProt: Q13451 Human
- Unigene: 407190 Human
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别名
- 51 kDa FK506 binding protein 5 antibody
- 51 kDa FK506 binding protein antibody
- 51 kDa FK506-binding protein antibody
see all
图片
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All lanes : Anti-FKBP51 antibody (ab2901) at 2 µg/ml
Lane 1 : K562 (human chronic myelogenous leukemia cell line from bone marrow) nuclear enriched extract
Lane 2 : HepG2 (human liver hepatocellular carcinoma cell line) nuclear enriched extract
Lane 3 : PC-3 (human prostate adenocarcinoma cell line) nuclear enriched extract
Lane 4 : MCF7 (human breast adenocarcinoma cell line) nuclear enriched extract
Lysates/proteins at 30 µg per lane.
Secondary
All lanes : Goat anti-Rabbit IgG (H+L) at 1/2500 dilutionApproximately 51 and 45 kDa bands corresponding to FKBP51 were observed across cell lines tested
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Anti-FKBP51 antibody (ab2901) at 2 µg/ml + HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (15)
ab2901 被引用在 15 文献中.
- Lu A et al. Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy. Sci Rep 10:7075 (2020). PubMed: 32341395
- Hadamitzky M et al. Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats. Int J Neuropsychopharmacol 21:592-602 (2018). PubMed: 29462337
- Criado-Marrero M et al. Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear. Learn Mem 24:145-152 (2017). PubMed: 28298552
- Li K et al. ELF5-Mediated AR Activation Regulates Prostate Cancer Progression. Sci Rep 7:42759 (2017). PubMed: 28287091
- Herring A et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement 12:1273-1287 (2016). PubMed: 27327541