FITC荧光Anti-C4c+C4b抗体(ab4216)
Key features and details
- FITC Rabbit polyclonal to C4c+C4b
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG
概述
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产品名称
FITC荧光Anti-C4c+C4b抗体 -
描述
FITC荧光兔多克隆抗体to C4c+C4b -
宿主
Rabbit -
偶联物
FITC. Ex: 493nm, Em: 528nm -
特异性
This antibody reacts with human C4, C4b and C4c but does not react with the C4d epitope. -
种属反应性
与反应: Human -
免疫原
C4c complement isolated from complement activated human serum.
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常规说明
Fluorescein isothiocyanate (FITC) isomer 1.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Isotype control
靶标
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相关性
C4 plays a central role in the activation of the classical pathway of the complement system. Human complement component C4 is polymorphic at two loci, C4A and C4B. The C4A alleles carry the Rodgers (Rg) while the C4B alleles carry the Chido (Ch) blood group antigens. C4 (either allele A or B) protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. -
细胞定位
Secreted -
数据库链接
- Entrez Gene: 720 Human
- Entrez Gene: 721 Human
- SwissProt: P0C0L4 Human
- SwissProt: P0C0L5 Human
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别名
- Acidic complement C4 antibody
- Basic complement C4 antibody
- CH antibody
see all
数据表及文件
文献 (1)
ab4216 被引用在 1 文献中.
- Ispasanie E et al. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence 9:1138-1149 (2018). PubMed: 30067453