重组Anti-FGFR4抗体[EPR5330(N)] (ab178396)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR5330(N)] to FGFR4
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
概述
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产品名称
Anti-FGFR4抗体[EPR5330(N)]
参阅全部 FGFR4 一抗 -
描述
兔单克隆抗体[EPR5330(N)] to FGFR4 -
宿主
Rabbit -
经测试应用
适用于: WBmore details
不适用于: Flow Cyt,ICC/IF,IHC-P or IP -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- SW480, SH-SY5Y, Raji and MOLT4 cell lysates.
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常规说明
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA -
Concentration information loading...
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纯度
Protein A purified -
克隆
单克隆 -
克隆编号
EPR5330(N) -
同种型
IgG -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab178396于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/5000. Predicted molecular weight: 88 kDa.
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说明 |
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WB
1/1000 - 1/5000. Predicted molecular weight: 88 kDa. |
靶标
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功能
Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19. -
组织特异性
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻译后修饰
Glycosylated.
Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization. -
细胞定位
Membrane. Isoform 2 may be secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2264 Human
- Entrez Gene: 14186 Mouse
- Entrez Gene: 25114 Rat
- Omim: 134935 Human
- SwissProt: P22455 Human
- SwissProt: Q03142 Mouse
- SwissProt: Q498D6 Rat
- Unigene: 165950 Human
see all -
别名
- CD 334 antibody
- CD334 antibody
- CD334 antigen antibody
see all
图片
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All lanes : Anti-FGFR4 antibody [EPR5330(N)] (ab178396) at 1/1000 dilution
Lane 1 : SW480 cell lysate
Lane 2 : SH-SY5Y cell lysate
Lane 3 : Raji cell lysate
Lane 4 : MOLT4 cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat anti-rabbit HRP at 1/2000 dilution
Developed using the ECL technique.
Predicted band size: 88 kDaThe expression profile observed is consistent with what has been described in the literature PMID: 15709206.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab178396 被引用在 4 文献中.
- Dong Z et al. Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis. Cell Mol Gastroenterol Hepatol 13:1161-1179 (2022). PubMed: 34990887
- Zhang D et al. Dexamethasone and lenvatinib inhibit migration and invasion of non-small cell lung cancer by regulating EKR/AKT and VEGF signal pathways. Exp Ther Med 19:762-770 (2020). PubMed: 31853327
- Ji S et al. FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis. Dev Cell 48:460-474.e9 (2019). PubMed: 30745141
- Wang J et al. Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice. Sci Rep 6:34117 (2016). WB ; Mouse . PubMed: 27666676