Anti-FGF10抗体(ab115825)
Key features and details
- Rabbit polyclonal to FGF10
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FGF10抗体
参阅全部 FGF10 一抗 -
描述
兔多克隆抗体to FGF10 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse -
免疫原
Synthetic peptide corresponding to a sequence at the N-terminal of Human FGF10.
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阳性对照
- U87, HeLa, A549, 293T and MCF7 whole cell lysates.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab115825于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa.
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说明 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 23 kDa. |
靶标
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功能
Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7. -
疾病相关
Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed. -
序列相似性
Belongs to the heparin-binding growth factors family. -
细胞定位
Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 2255 Human
- Entrez Gene: 14165 Mouse
- Omim: 602115 Human
- SwissProt: O15520 Human
- SwissProt: O35565 Mouse
- Unigene: 664499 Human
- Unigene: 317323 Mouse
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别名
- BB213776 antibody
- fd11d03 antibody
- FGF 10 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab115825 被引用在 1 文献中.
- Li YH et al. Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-?B-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice. Sci Rep 6:19869 (2016). Mouse . PubMed: 26813160