Anti-FBXL3抗体(ab96645)
Key features and details
- Rabbit polyclonal to FBXL3
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-FBXL3抗体
参阅全部 FBXL3 一抗 -
描述
兔多克隆抗体to FBXL3 -
宿主
Rabbit -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Zebrafish -
免疫原
Recombinant protein fragment corresponding to a region within amino acids 14 and 279 of Human FBXL3 (NP_036290).
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阳性对照
- 293T, H1299, HeLa, HepG2 and Raji cell lines. MOLT4 whole cell lysate and A431 cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab96645于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 49 kDa.
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ICC/IF |
1/100 - 1/200.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 49 kDa. |
ICC/IF
1/100 - 1/200. |
靶标
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功能
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex involved in circadian clock function. The SCF(FBXL3) complex acts by mediating ubiquitination and subsequent degradation of CRY1 and CRY2. Recruiter of target protein that may recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation. -
组织特异性
Widely expressed. -
序列相似性
Contains 1 F-box domain.
Contains 7 LRR (leucine-rich) repeats. -
细胞定位
Nucleus. Cytoplasm. Predominantly nuclear. - Information by UniProt
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数据库链接
- Entrez Gene: 26224 Human
- Entrez Gene: 50789 Mouse
- Entrez Gene: 306129 Rat
- Omim: 605653 Human
- SwissProt: Q9UKT7 Human
- SwissProt: Q8C4V4 Mouse
- Unigene: 508284 Human
- Unigene: 214746 Mouse
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别名
- F box and leucine rich repeat protein 3 antibody
- F box and leucine rich repeat protein 3A antibody
- F box protein Fbl3a antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab96645 被引用在 3 文献中.
- Ashraf NS et al. Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein. Neurobiol Dis 137:104697 (2020). PubMed: 31783119
- Toledo M et al. Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab 28:268-281.e4 (2018). PubMed: 29937374
- Wang D et al. FBXL3 is regulated by miRNA-4735-3p and suppresses cell proliferation and migration in non-small cell lung cancer. Pathol Res Pract N/A:N/A (2018). PubMed: 30594330