Anti-FANCG抗体(ab5067)

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Key features and details

  • Rabbit polyclonal to FANCG
  • Suitable for: WB
  • Reacts with: Human
  • Isotype: IgG

概述

  • 产品名称

    Anti-FANCG抗体
    参阅全部 FANCG 一抗

  • 描述

    兔多克隆抗体to FANCG

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WBmore details

  • 种属反应性

    与反应: Human

  • 免疫原

    Synthetic peptide:

    MSRQTTSVGSSC

    , corresponding to amino acids 1 - 12 of Human FANCG.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 阳性对照

    • Recombinant Human FANCG protein (ab114925) can be used as a positive control in WB.

  • 常规说明

    Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of opening.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 存储溶液

    Preservative: 0.01% Sodium azide
    Constituents: 0.424% Potassium phosphate, 0.878% Sodium chloride
  • Concentration information loading...

  • 纯度

    Immunogen affinity purified

  • 克隆

    多克隆

  • 同种型

    IgG

  • 研究领域

应用

Our Abpromise guarantee covers the use of ab5067 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).

靶标

  • 功能

    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

  • 组织特异性

    Highly expressed in testis and thymus. Found in lymphoblasts.

  • 疾病相关

    Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.

  • 序列相似性

    Contains 4 TPR repeats.

  • 细胞定位

    Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt

  • 数据库链接

    • 别名

      • DNA repair protein XRCC9 antibody
      • FAG antibody
      • FANCG antibody
      • FANCG_HUMAN antibody
      • Fanconi anaemia complementation group G antibody
      • Fanconi anemia group G protein antibody
      • Protein FACG antibody
      • X ray repair, complementing defective, in Chinese hamster cells 9 antibody
      • X-ray repair, complementing defective, in Chinese hamster, 9 antibody
      • XRCC9 antibody
      see all

    图片

    • Western blot - Anti-FANCG antibody (ab5067)
      Western blot - Anti-FANCG antibody (ab5067)
      Anti-FANCG antibody (ab5067) at 1/500 dilution + HeLa whole cell lysate at 35 µg

      Secondary
      IRDye 800 conjugated Goat anti-Rabbit IgG [H&L] at 1/10000 dilution

      Performed under reducing conditions.

      Predicted band size: 69 kDa
      Observed band size: 69 kDa
      Additional bands at: 11 kDa, 24 kDa. We are unsure as to the identity of these extra bands.

    文献 (2)

    发表研究结果有使用 ab5067？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab5067 被引用在 2 文献中.

    • Gonsalvez DG  et al. Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy. Front Mol Neurosci 12:275 (2019). PubMed: 31803018
    • Song ZP  et al. Minocycline attenuates bone cancer pain in rats by inhibiting NF-?B in spinal astrocytes. Acta Pharmacol Sin 37:753-62 (2016). PubMed: 27157092

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