Factor XIa Assay试剂盒(ab241037)
Key features and details
- Detection method: Colorimetric
概述
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产品名称
Factor XIa Assay试剂盒 -
检测方法
Colorimetric -
产品概述
The Factor XIa Assay Kit (ab241037) utilizes the ability of factor XIa to cleave a synthetic substrate to release p-Nitroaniline (pNA) which can be quantitatively measured by a colorimetric assay (OD 405 nm).
The kit is easy-to-use and can detect Factor XIa (as low as 1 mPEU) from plasma and purified protein samples.
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说明
This product is manufactured by BioVision, an Abcam company and was previously called K973 Factor XIa Activity Assay Kit (Colorimetric). K973-100 is the same size as the 100 test size of ab241037.
性能
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存放说明
Store at -20°C. Please refer to protocols. -
组件 100 tests Assay Buffer XXXV 1 x 25ml FXIa Activator 1 x 1ml FXIa Substrate 1 x 1ml FXIIa Inhibitor 1 x 0.1ml Human Factor XIa 1 vial PK Inhibitor 1 x 0.1ml pNA Standard I 1 x 20µl -
研究领域
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功能
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. -
组织特异性
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. -
疾病相关
Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. -
序列相似性
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Contains 4 apple domains.
Contains 1 peptidase S1 domain. -
翻译后修饰
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen. -
细胞定位
Secreted. - Information by UniProt
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别名
- coagulation factor XI
- Coagulation factor XIa light chain
- F11
see all
图片
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Kinetic progressive curves for different amounts of FXIa Enzyme.
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Kinetic progressive curves for different amounts Activated Plasma Samples.
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Standard curve for pNA.
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Standard curve for pNA (n = 3) was used to estimate FXIa activity in plasma (n = 5). Assays were performed according to the kit protocol.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab241037 尚未被引用在任何文献中。