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您有没有想过:“在哪里再次找到组蛋白修饰?是活性启动子还是增强子?”如果有这样的需求,我们已经为您归纳在本指南中,不必再返回文献中去寻找!
我们列出了最常见的组蛋白修饰和其标记的基因组区域,即您可以在 ChIP/ChIP seq 实验的哪些位置找到它们。另外,我们还列出了识别组蛋白修饰最具特异性的抗体。
Histone mark | Where to find it | Antibody |
H3K4me1 | Active enhancers | ab176877 |
H3K4me3 | Promoters of active genes, bivalent domains | ab8580 |
H3K9ac | Active enhancers and promoters | ab177177 |
H3K27ac | Active enhancers and promoters | ab177178 |
H3K36me3 | Transcribed regions | ab9050 |
H3K79me2 | Transcribed regions | ab177184 |
H3K9me3 | Heterochromatin, satellite repeats, gene-poor regions | ab176916 |
H3K27me3 | Repressed promoters in gene-rich regions, developmental regulators, bivalent domains | ab192985 |
Gamma H2A.X | DNA double-strand breaks | ab81299 |
H3S10P | Whole chromosomes in mitosis | ab177218 |
H4K16ac | Reduced in cancer at repetitive sequences, active genes and enhancers in ESCs. Inhibits formation of high order chromatin structure. | ab109463 |
绿色 = 通常具有转录活性区;红色 = 通常具有转录抑制区;灰色 = 其他功能。
参考文献: