Anti-S1P1/EDG1 (phospho T236)抗体(ab111571)
Key features and details
- Rabbit polyclonal to S1P1/EDG1 (phospho T236)
- Suitable for: ICC/IF
- Reacts with: African green monkey
- Isotype: IgG
概述
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产品名称
Anti-S1P1/EDG1 (phospho T236)抗体
参阅全部 S1P1/EDG1 一抗 -
描述
兔多克隆抗体to S1P1/EDG1 (phospho T236) -
宿主
Rabbit -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: African green monkey
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human S1P1/EDG1 (phospho T236).
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阳性对照
- COS-7 cells.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab111571 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab111571于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/100 - 1/500.
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说明 |
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ICC/IF
1/100 - 1/500. |
靶标
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功能
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. -
组织特异性
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 13609 Mouse
- Entrez Gene: 29733 Rat
- SwissProt: O08530 Mouse
- SwissProt: P48303 Rat
- Unigene: 982 Mouse
- Unigene: 109455 Rat
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别名
- CD363 antibody
- CHEDG 1 antibody
- CHEDG1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab111571 被引用在 1 文献中.
- Yang CH et al. Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. Cell Rep 30:959-968.e3 (2020). PubMed: 31995766