Anti-EBV Latent膜蛋白1抗体[CS 1-4] (ab78113)
Key features and details
- Mouse monoclonal [CS 1-4] to EBV Latent Membrane Protein 1
- Suitable for: WB, IP, IHC-P, IHC-Fr
- Isotype: IgG1
概述
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产品名称
Anti-EBV Latent膜蛋白1抗体[CS 1-4]
参阅全部 EBV Latent Membrane Protein 1 一抗 -
描述
小鼠单克隆抗体[CS 1-4] to EBV Latent膜蛋白1 -
宿主
Mouse -
特异性
This antibody is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This is in fact four pooled antibodies which collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates. -
经测试应用
适用于: WB, IP, IHC-P, IHC-Frmore details -
种属反应性
与反应: Epstein-Barr virus -
免疫原
Fusion protein corresponding to EBV Latent Membrane Protein 1.
Database link: P03230 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Affinity chromatography -
克隆
单克隆 -
克隆编号
CS 1-4 -
骨髓瘤
x63-Ag8.653 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab78113于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.
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IP |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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说明 |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 42 kDa. |
IP
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
靶标
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相关性
EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. -
数据库链接
- Entrez Gene: 3783750 Epstein-Barr virus
- SwissProt: P0C741 Epstein-Barr virus
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别名
- BNLF1 antibody
- EBV antibody
- Epstein Barr virus antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (38)
ab78113 被引用在 38 文献中.
- Sidorov S et al. CD4 + T cells are found within endemic Burkitt lymphoma and modulate Burkitt lymphoma precursor cell viability and expression of pathogenically relevant Epstein-Barr virus genes. Cancer Immunol Immunother 71:1371-1392 (2022). PubMed: 34668039
- Zhu N et al. Epstein-Barr Virus LMP1-Activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties. J Virol 96:e0194121 (2022). PubMed: 35019715
- Zvejniece L et al. Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2. Int J Mol Sci 23:N/A (2022). PubMed: 35408790
- Caruso LB et al. The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. PLoS Pathog 18:e1010400 (2022). PubMed: 35421198
- Singh DR et al. Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes. PLoS Pathog 18:e1010868 (2022). PubMed: 36190982