Anti-DREAM抗体(ab3474)

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Key features and details

  • Rabbit polyclonal to DREAM
  • Suitable for: ICC/IF
  • Reacts with: Rat, Rabbit, Human, Non human primates
  • Isotype: IgG

概述

  • 产品名称

    Anti-DREAM抗体
    参阅全部 DREAM 一抗

  • 描述

    兔多克隆抗体to DREAM

  • 宿主

    Rabbit

  • 特异性

    Detects KChIP 3 from rabbit cerebellar granule cells.

  • 经测试应用

    适用于: ICC/IFmore details

  • 种属反应性

    与反应: Rat, Rabbit, Human, Non human primates
    预测可用于: Mouse

  • 免疫原

    Synthetic peptide corresponding to Mouse DREAM aa 30-45.
    Sequence:

    IKWQRPRFTRQALMRC


    (Peptide available as ab5866)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • 常规说明

    Previously labelled as CSEN. 

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

性能

应用

Our Abpromise guarantee covers the use of ab3474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能

    Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
    May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.

  • 组织特异性

    Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.

  • 序列相似性

    Belongs to the recoverin family.
    Contains 4 EF-hand domains.

  • 翻译后修饰

    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
    Proteolytically cleaved by caspase-3.
    Phosphorylation at Ser-63 inhibits cleavage by CASP3.

  • 细胞定位

    Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
  • Information by UniProt

  • 数据库链接

    see all

  • 别名

    • 4933407H12Rik antibody
    • A type potassium channel modulatory protein 3 antibody
    • A-type potassium channel modulatory protein 3 antibody
    • AI413860 antibody
    • Calsenilin antibody
    • CSEN antibody
    • CSEN_HUMAN antibody
    • DRE antagonist modulator antibody
    • DRE-antagonist modulator antibody
    • DREAM antibody
    • EF hand transcription factor antibody
    • KCHIP 3 antibody
    • KChIP3 antibody
    • KCNIP 3 antibody
    • Kcnip3 antibody
    • Kv channel interacting protein 3 antibody
    • Kv channel-interacting protein 3 antibody
    • MGC18289 antibody
    • Potassium channel interacting protein 3 antibody
    • R74849 antibody
    see all

图片

  • Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (ab3474)
    Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (ab3474)

    Immunolocalization of DREAM in Rabbit granule cells using ab3474.

文献 (1)

发表研究结果有使用 ab3474？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab3474 被引用在 1 文献中.

  • Tian NX  et al. KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats. J Neurosci 38:1756-1773 (2018). PubMed: 29335353

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