Anti-DGAT2抗体(ab59493)
Key features and details
- Goat polyclonal to DGAT2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-DGAT2抗体
参阅全部 DGAT2 一抗 -
描述
山羊多克隆抗体to DGAT2 -
宿主
Goat -
特异性
This antibody is not expected to cross-react with other DGAT members. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Dog -
免疫原
Synthetic peptide:
C-KLEHPTQQDIDLYH
, corresponding to C terminal amino acids 346-359 of Human DGAT2 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab59493于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 3 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. |
靶标
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功能
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. -
组织特异性
Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. -
通路
Glycerolipid metabolism; triacylglycerol biosynthesis. -
序列相似性
Belongs to the diacylglycerol acyltransferase family. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 404129 Cow
- Entrez Gene: 84649 Human
- Entrez Gene: 67800 Mouse
- Entrez Gene: 252900 Rat
- SwissProt: Q70VZ8 Cow
- SwissProt: Q96PD7 Human
- SwissProt: Q9DCV3 Mouse
- SwissProt: Q5FVP8 Rat
see all -
别名
- DGAT2 antibody
- DGAT2_HUMAN antibody
- Diacylglycerol O acyltransferase like protein 2 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (9)
ab59493 被引用在 9 文献中.
- Zhang JF et al. Overexpression of DGAT2 Stimulates Lipid Droplet Formation and Triacylglycerol Accumulation in Bovine Satellite Cells. Animals (Basel) 12:N/A (2022). PubMed: 35883393
- O'Brien PD et al. Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes. Dis Model Mech 13:N/A (2020). PubMed: 31822493
- do Carmo JM et al. Impact of leptin deficiency compared with neuronal-specific leptin receptor deletion on cardiometabolic regulation. Am J Physiol Regul Integr Comp Physiol 317:R552-R562 (2019). PubMed: 31411897
- Jia H et al. Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly. J Dairy Sci 102:833-845 (2019). PubMed: 30415861
- Howie D et al. A Novel Role for Triglyceride Metabolism in Foxp3 Expression. Front Immunol 10:1860 (2019). PubMed: 31456800
- Balaban S et al. Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Mol Cancer Res 17:949-962 (2019). PubMed: 30647103
- Nagarajan SR et al. Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism. Am J Physiol Endocrinol Metab 316:E578-E589 (2019). PubMed: 30694691
- Trogen G et al. Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation. Am J Physiol Endocrinol Metab 315:E949-E960 (2018). PubMed: 29763374
- Alonso C et al. Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. Gastroenterology 152:1449-1461.e7 (2017). PubMed: 28132890