Anti-Desmocollin 2抗体(ab95967)
Key features and details
- Rabbit polyclonal to Desmocollin 2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-Desmocollin 2抗体
参阅全部 Desmocollin 2 一抗 -
描述
兔多克隆抗体to Desmocollin 2 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Recombinant fragment, corresponding to a region within amino acids 480-676 of Human Desmocollin 2 isoform 2A and 2B (Uniprot ID = Q02487).
-
阳性对照
- WB: A431 cells. IHC-P: OVCAR3 xenograft.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95967于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 94 kDa.
|
IHC-P | (1) |
1/100 - 1/1000.
|
说明 |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 94 kDa. |
IHC-P
1/100 - 1/1000. |
靶标
-
功能
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. -
组织特异性
Expressed in epithelia, myocardium and lymph nodes. -
疾病相关
Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. -
序列相似性
Contains 5 cadherin domains. -
结构域
Calcium may be bound by the cadherin-like repeats. -
细胞定位
Cell membrane. Cell junction > desmosome. - Information by UniProt
-
数据库链接
- Entrez Gene: 1824 Human
- Omim: 125645 Human
- SwissProt: Q02487 Human
- Unigene: 95612 Human
-
别名
- ARVD11 antibody
- Cadherin family member 2 antibody
- CDHF2 antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (3)
ab95967 被引用在 3 文献中.
- Roberson PA et al. LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle. Front Nutr 7:628405 (2020). PubMed: 33521042
- Gumber S et al. Immunohistological characterization of intercellular junction proteins in rhesus macaque intestine. Exp Toxicol Pathol 66:437-44 (2014). PubMed: 25153024
- Resnik N et al. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 286:1499-507 (2011). WB ; Dog . PubMed: 21071449