Anti-REDD-1/DDIT4抗体(ab106356)
Key features and details
- Rabbit polyclonal to REDD-1/DDIT4
- Suitable for: ICC/IF, IHC-P
- Reacts with: Mouse
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-REDD-1/DDIT4抗体
参阅全部 REDD-1/DDIT4 一抗 -
描述
兔多克隆抗体to REDD-1/DDIT4 -
宿主
Rabbit -
经测试应用
适用于: ICC/IF, IHC-Pmore details
不适用于: WB -
种属反应性
与反应: Mouse
预测可用于: Human -
免疫原
Synthetic peptide corresponding to Human REDD-1/DDIT4 (internal sequence).
Database link: NP_061931 -
阳性对照
- IHC-P: Mouse kidney tissue. ICC/IF: Mouse kidney tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106356于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
Use at an assay dependent concentration.
ICC/IF for Mouse samples only |
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
IHC-P for Mouse samples only |
说明 |
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ICC/IF
Use at an assay dependent concentration. ICC/IF for Mouse samples only |
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. IHC-P for Mouse samples only |
靶标
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功能
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. -
组织特异性
Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). -
序列相似性
Belongs to the DDIT4 family. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 54541 Human
- Entrez Gene: 74747 Mouse
- Omim: 607729 Human
- SwissProt: Q9NX09 Human
- SwissProt: Q9D3F7 Mouse
- Unigene: 523012 Human
- Unigene: 21697 Mouse
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别名
- DDIT4 antibody
- DDIT4_HUMAN antibody
- Dig2 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (8)
ab106356 被引用在 8 文献中.
- Yang Z & Xia L Resveratrol inhibits the proliferation, invasion, and migration, and induces the apoptosis of human gastric cancer cells through the MALAT1/miR-383-5p/DDIT4 signaling pathway. J Gastrointest Oncol 13:985-996 (2022). PubMed: 35837196
- Huang P et al. Redd1 knockdown prevents doxorubicin-induced cardiac senescence. Aging (Albany NY) 13:13788-13806 (2021). PubMed: 33962393
- Jeong H et al. Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-?B Activation. Int J Mol Sci 21:N/A (2020). PubMed: 32998341
- Huang P et al. Redd1 protects against post-infarction cardiac dysfunction by targeting apoptosis and autophagy. Int J Mol Med 44:2065-2076 (2019). PubMed: 31638187
- Mains RE et al. Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine a-Amidating Monooxygenase. Endocrinology 159:2621-2639 (2018). PubMed: 29788427
- Gupta I et al. Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis. Proc Natl Acad Sci U S A 113:E4208-17 (2016). PubMed: 27382160
- Zhao H et al. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization. Int J Mol Sci 17:N/A (2016). PubMed: 27898044
- Polioudakis D et al. A Myc-microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes. Nucleic Acids Res 41:2239-54 (2013). PubMed: 23303785