Anti-Cytomegalovirus pp65抗体[3A12] - BSA and Azide free (ab6503)

Submit a review Q&A (2)References (12)

Key features and details

  • Mouse monoclonal [3A12] to Cytomegalovirus pp65 - BSA and Azide free
  • Suitable for: WB, ICC/IF
  • Isotype: IgG2a

概述

  • 产品名称

    Anti-Cytomegalovirus pp65抗体[3A12] - BSA and Azide free
    参阅全部 Cytomegalovirus pp65 一抗

  • 描述

    小鼠单克隆抗体[3A12] to Cytomegalovirus pp65 - BSA and Azide free

  • 宿主

    Mouse

  • 特异性

    Cytomegalovirus pp65 (Lower Matrix Protein).

  • 经测试应用

    适用于: WB, ICC/IFmore details

  • 种属反应性

    与反应: Other species

  • 免疫原

    Cytomegalovirus

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 存储溶液

    pH: 7.40
    Constituent: 100% PBS

  • 无载体

    是
  • Concentration information loading...

  • 纯度

    Protein A purified

  • 克隆

    单克隆

  • 克隆编号

    3A12

  • 骨髓瘤

    NS1/1-Ag4-1

  • 同种型

    IgG2a

  • 轻链类型

    kappa

  • 研究领域

应用

Our Abpromise guarantee covers the use of ab6503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/16000.
ICC/IF 1/3200.

靶标

  • 相关性

    Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens.

  • 别名

    • 65 kDa matrix phosphoprotein antibody
    • 65 kDa phosphoprotein antibody
    • Tegument protein pp65 antibody
    • Tegument protein UL83 antibody

文献 (12)

发表研究结果有使用 ab6503？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab6503 被引用在 12 文献中.

  • Liu X  et al. Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor. Nat Commun 10:3020 (2019). PubMed: 31289263
  • Ye X  et al. Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection. PLoS Pathog 15:e1007914 (2019). PubMed: 31356650
  • Liu B  et al. Recombinant human growth hormone treatment of mice suppresses inflammation and apoptosis caused by skin flap ischemia-reperfusion injury. J Cell Biochem 120:18162-18171 (2019). PubMed: 31144385
  • Chen X & Zhu B Steroid Receptor Coactivator-Interacting Protein (SIP) Suppresses Myocardial Injury Caused by Acute Pancreatitis. Med Sci Monit 24:3204-3211 (2018). PubMed: 29765014
  • Cao J  et al. Identification of microRNA-124 in regulation of Hepatocellular carcinoma through BIRC3 and the NF-?B pathway. J Cancer 9:3006-3015 (2018). PubMed: 30210622
View all Publications for this product

客户评价及客户问答

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Question

Hi, We are interested in antibodies against human CMV pp65. We don't need the antibody for the whole pp65 protein, rather we need the AB for a certain epitope. please send us your info. Thanks.

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Answer

Thank you for your inquiry. As you may have seen already, we have a number of HCMV pp65 antibodies available in our catalog (such as ab6503, ab8250, ab31624, ab49214, ab53489). These were raised against the pp65 protein, however, unfortunately the exact epitope recognised by each antibody has not been mapped, as epitope mapping is not routinely performed.  I am sorry that I cannot be more helpful on this occasion. Please do not hesitate to contact us if you have any further questions.  

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Question

I am looking for an antibody to pp65 that will recognize epitopes beyond those found in the terminal third of the pp65 coding sequence - do you know what region of pp65 this antibody recognizes? I do not need specifics, just whether this product will work for me.

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Answer

I put your question forward to the originator but they said that the epitope has not been characterised so they do not have the information. I am sorry we cannot be of help to you.

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