Anti-Cytomegalovirus pp65抗体[3A12] - BSA and Azide free (ab6503)

Submit a review Q&A (2)References (23)

Key features and details

  • Mouse monoclonal [3A12] to Cytomegalovirus pp65 - BSA and Azide free
  • Suitable for: WB, ICC/IF
  • Isotype: IgG2a

概述

  • 产品名称

    Anti-Cytomegalovirus pp65抗体[3A12] - BSA and Azide free
    参阅全部 Cytomegalovirus pp65 一抗

  • 描述

    小鼠单克隆抗体[3A12] to Cytomegalovirus pp65 - BSA and Azide free

  • 宿主

    Mouse

  • 特异性

    Cytomegalovirus pp65 (Lower Matrix Protein).

  • 经测试应用

    适用于: WB, ICC/IFmore details

  • 种属反应性

    与反应: Other species

  • 免疫原

    Tissue, cells or virus corresponding to Cytomegalovirus pp65.

  • 常规说明

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

性能

  • 形式

    Liquid

  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 存储溶液

    pH: 7.40
    Constituent: 100% PBS

  • 无载体

    是
  • Concentration information loading...

  • 纯度

    Protein A purified

  • 克隆

    单克隆

  • 克隆编号

    3A12

  • 骨髓瘤

    NS1/1-Ag4-1

  • 同种型

    IgG2a

  • 轻链类型

    kappa

  • 研究领域

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab6503于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/16000.
ICC/IF
1/3200.
说明
WB
1/16000.
ICC/IF
1/3200.

靶标

  • 相关性

    Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens.

  • 别名

    • 65 kDa matrix phosphoprotein antibody
    • 65 kDa phosphoprotein antibody
    • Tegument protein pp65 antibody
    • Tegument protein UL83 antibody

文献 (23)

发表研究结果有使用 ab6503？请让我们知道，以便我们可以引用本数据表中的参考文章。

ab6503 被引用在 23 文献中.

  • Vezzani G  et al. The Human Cytomegalovirus UL116 Glycoprotein Is a Chaperone to Control gH-Based Complexes Levels on Virions. Front Microbiol 12:630121 (2021). PubMed: 33889136
  • Le-Trilling VTK  et al. The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity. Cell Rep 30:2248-2260.e5 (2020). PubMed: 32075763
  • Zhao C  et al. GOLPH3 Promotes Angiogenesis of Lung Adenocarcinoma by Regulating the Wnt/ß-Catenin Signaling Pathway. Onco Targets Ther 13:6265-6277 (2020). PubMed: 32636646
  • Li D  et al. Astragaloside IV protects ATDC5 cells from lipopolysaccharide-caused damage through regulating miR-203/MyD88. Pharm Biol 58:89-97 (2020). PubMed: 31906765
  • Liu W  et al. TRIP6 regulates the proliferation, migration, invasion and apoptosis of osteosarcoma cells by activating the NF-?B signaling pathway. Exp Ther Med 19:2317-2325 (2020). PubMed: 32104300
View all Publications for this product

客户评价及客户问答

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1-2 of 2 Abreviews or Q&A

Question

Hi, We are interested in antibodies against human CMV pp65. We don't need the antibody for the whole pp65 protein, rather we need the AB for a certain epitope. please send us your info. Thanks.

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Answer

Thank you for your inquiry. As you may have seen already, we have a number of HCMV pp65 antibodies available in our catalog (such as ab6503, ab8250, ab31624, ab49214, ab53489). These were raised against the pp65 protein, however, unfortunately the exact epitope recognised by each antibody has not been mapped, as epitope mapping is not routinely performed.  I am sorry that I cannot be more helpful on this occasion. Please do not hesitate to contact us if you have any further questions.  

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Question

I am looking for an antibody to pp65 that will recognize epitopes beyond those found in the terminal third of the pp65 coding sequence - do you know what region of pp65 this antibody recognizes? I do not need specifics, just whether this product will work for me.

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Answer

I put your question forward to the originator but they said that the epitope has not been characterised so they do not have the information. I am sorry we cannot be of help to you.

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