Anti-Cytokeratin 8+18抗体[5D3]，prediluted (ab847)
概述
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产品名称Anti-Cytokeratin 8+18抗体[5D3]，prediluted
参阅全部 Cytokeratin 8+18 一抗 -
描述小鼠单克隆抗体[5D3] to Cytokeratin 8+18，prediluted
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宿主Mouse
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特异性This antibody is specific to human cytokeratins 8 (52.5 kDa) and 18 (45 kDa). This antibody stains simple and glandular epithelium. This antibody can be useful for the identification of adenocarcinomas and most squamous cell carcinomas.
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经测试应用适用于: IHC-P, IHC-Frmore details
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种属反应性与反应: Human
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免疫原
Human breast carcinoma cell line MCF-7.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C. Do Not Freeze.
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存储溶液Preservative: 0.05% Sodium azide
Inert stabilizer -
Concentration information loading... -
克隆单克隆
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克隆编号5D3
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骨髓瘤unknown
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同种型IgG1
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研究领域
相关产品
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Alternative Versions
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Compatible Secondaries
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Isotype control
应用
Our Abpromise guarantee covers the use of ab847 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
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| IHC-P | Use at an assay dependent concentration. This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. We suggest an incubation period of 60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Proteolytic treatment is required prior to immunostaining of formalin fixed paraffin embedded tissue sections. |
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| IHC-Fr | Use at an assay dependent concentration. |
靶标
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相关性Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. Disease: Cirrhosis Similarity: Belongs to the intermediate filament family. PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
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细胞定位Cytoplasmic
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数据库链接
- Entrez Gene: 3856 Human
- Entrez Gene: 3875 Human
- Omim: 148060 Human
- Omim: 148070 Human
- SwissProt: P05787 Human
- Unigene: 406013 Human
- Unigene: 533782 Human
- Unigene: 708445 Human
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别名
- CARD2 antibody
- Cell proliferation inducing gene 46 protein antibody
- Cell proliferation inducing protein 46 antibody
see all
图片
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 8+18 antibody [5D3], prediluted (ab847)](https://www.abcam.cn/ps/products/0/ab847/Images/ab847-255298-PDM070Cytokeratin8185D3.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 8+18 antibody [5D3], prediluted (ab847)Immunohistochemical analysis of formalin-fixed paraffin-embedded human skin tissue sections, labelling Cytokeratin 8/18 with ab847.
数据表及文件
文献
ab847 has not yet been referenced specifically in any publications.
