存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline
Concentration information loading...
纯度Immunogen affinity purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
Our Abpromise guarantee covers the use of ab113640 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 3.75 µg/ml.|
功能Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
组织特异性Highly expressed in brain, particularly in the cerebellum and pons.
疾病相关Radiohumeral fusions with other skeletal and craniofacial anomalies
序列相似性Belongs to the cytochrome P450 family.
细胞定位Endoplasmic reticulum membrane. Microsome membrane.
- Information by UniProt
- CP26 antibody
- CP26B_HUMAN antibody
- CYP26A2 antibody
ab113640, at 3.75 µg/ml, staining Cytochrome P450 26B in formalin fixed, paraffin embedded Human small intestine (submucosal plexus) tissue by Immunohistochemistry.
ab113640, at 3.75 µg/ml, staining Cytochrome P450 26B in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.
ab113640, at 3.75 µg/ml, staining Cytochrome P450 26B in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.
ab113640 has not yet been referenced specifically in any publications.