Anti-Cyclin A1抗体(ab133183)
Key features and details
- Rabbit polyclonal to Cyclin A1
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Cyclin A1抗体
参阅全部 Cyclin A1 一抗 -
描述
兔多克隆抗体to Cyclin A1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide from the C-terminal region of Human Cyclin A1.
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阳性对照
- SKOV3 cell extract; Human testis tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab133183于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 52 kDa.
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 52 kDa. |
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. -
组织特异性
Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines. -
序列相似性
Belongs to the cyclin family. Cyclin AB subfamily. -
发展阶段
Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 8900 Human
- Entrez Gene: 12427 Mouse
- Entrez Gene: 295052 Rat
- Omim: 604036 Human
- SwissProt: P78396 Human
- SwissProt: Q61456 Mouse
- SwissProt: Q6AY13 Rat
- Unigene: 417050 Human
see all -
别名
- CCN A1 antibody
- CCNA 1 antibody
- Ccna1 antibody
see all
图片
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All lanes : Anti-Cyclin A1 antibody (ab133183) at 1/500 dilution
Lane 1 : SKOV3 cell extract
Lane 2 : SKOV3 cell extract with synthesized
peptide
Predicted band size: 52 kDa -
Immunohistochemical analysis of paraffin embedded Human testis tissue labelling Cyclin A1 with ab133183 antibody at a concentration of 5 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab133183 被引用在 4 文献中.
- Li S & Tu H Psoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells. Folia Histochem Cytobiol 60:101-109 (2022). PubMed: 35257357
- Wu Y et al. The Transcriptional Cell Atlas of Testis Development in Sheep at Pre-Sexual Maturity. Curr Issues Mol Biol 44:483-497 (2022). PubMed: 35723319
- Wang F et al. Degradation of CCNB1 mediated by APC11 through UBA52 ubiquitination promotes cell cycle progression and proliferation of non-small cell lung cancer cells. Am J Transl Res 11:7166-7185 (2019). PubMed: 31814919
- Li F et al. CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells. Oncol Lett 15:4789-4796 (2018). PubMed: 29552118