存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
存储溶液Preservative: 0.09% Sodium azide
Constituents: 2% Sucrose, PBS
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纯度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab104321 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
功能Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
组织特异性Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
Contains 1 protein kinase domain.
翻译后修饰Autophosphorylates on all three types of residues.
- Information by UniProt
- AI987988 antibody
- C85119 antibody
- CDC like kinase 4 antibody
This product has been referenced in:
- Petsalaki E & Zachos G Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Nat Commun 7:11451 (2016). Read more (PubMed: 27126587) »
- Nubile M et al. S100 A and B expression in normal and inflamed human limbus. Mol Vis 19:146-52 (2013). Read more (PubMed: 23378728) »