Anti-Cleaved Caspase-6抗体(ab2326)
Key features and details
- Rabbit polyclonal to Cleaved Caspase-6
- Reacts with: Rat, Human
- Isotype: IgG
概述
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产品名称
Anti-Cleaved Caspase-6抗体 -
描述
兔多克隆抗体to Cleaved Caspase-6 -
宿主
Rabbit -
特异性
This antibody recognizes the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize any other caspase.
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种属反应性
与反应: Rat, Human -
免疫原
Synthetic peptide corresponding to Human Cleaved Caspase-6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.
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常规说明
The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
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性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
Primary antibody说明
The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
靶标
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功能
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. -
序列相似性
Belongs to the peptidase C14A family. -
翻译后修饰
Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 839 Human
- Entrez Gene: 83584 Rat
- Omim: 601532 Human
- SwissProt: P55212 Human
- SwissProt: O35397 Rat
- Unigene: 3280 Human
- Unigene: 654616 Human
- Unigene: 88160 Rat
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别名
- active caspase 6 antibody
- Apoptotic protease Mch-2 antibody
- Apoptotic protease MCH2 antibody
see all
文献 (3)
ab2326 被引用在 3 文献中.
- He Y et al. CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. Cell Death Dis 11:358 (2020). PubMed: 32398664
- Zhou J et al. CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis 10:885 (2019). PubMed: 31767835
- Li X et al. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal 21:1675-92 (2014). Mouse . PubMed: 24483844
