Key features and details
- Rabbit polyclonal to Cleaved Caspase-6
- Reacts with: Rat, Human
- Isotype: IgG
描述兔多克隆抗体to Cleaved Caspase-6
This antibody recognizes the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize any other caspase.
种属反应性与反应: Rat, Human
Synthetic peptide corresponding to Human Cleaved Caspase-6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.
The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 30% Glycerol, 0.5% BSA
Concentration information loading...
纯度Immunogen affinity purified
Primary antibody说明The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
功能Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
序列相似性Belongs to the peptidase C14A family.
翻译后修饰Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
- Information by UniProt
- active caspase 6 antibody
- Apoptotic protease Mch-2 antibody
- Apoptotic protease MCH2 antibody
ab2326 被引用在 3 文献中.
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- Zhou J et al. CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis 10:885 (2019). PubMed: 31767835
- Li X et al. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal 21:1675-92 (2014). Mouse . PubMed: 24483844