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Anti-Cleaved Caspase-6抗体(ab2326)

  • Datasheet
  • SDS
Reviews (1)Q&A (3)References (3)

Product price, shipping and contact information

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Key features and details

  • Rabbit polyclonal to Cleaved Caspase-6
  • Reacts with: Rat, Human
  • Isotype: IgG

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概述

  • 产品名称

    Anti-Cleaved Caspase-6抗体
  • 描述

    兔多克隆抗体to Cleaved Caspase-6
  • 宿主

    Rabbit
  • 特异性

    This antibody recognizes the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize any other caspase.

  • 种属反应性

    与反应: Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human Cleaved Caspase-6. Synthetic peptide surrounding amino acids mapping to the C-terminus of the large fragment of Human Caspase-6.

  • 常规说明

    The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

性能

  • 形式

    Liquid
  • 存放说明

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液

    pH: 7.20
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 30% Glycerol, 0.5% BSA
  • Concentration information loading...
  • 纯度

    Immunogen affinity purified
  • Primary antibody说明

    The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
  • 克隆

    多克隆
  • 同种型

    IgG
  • 研究领域

    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Alzheimer's disease
    • Other
    • Cell Biology
    • Apoptosis
    • Intracellular
    • Caspases etc
    • Caspases

相关产品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

靶标

  • 功能

    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
  • 序列相似性

    Belongs to the peptidase C14A family.
  • 翻译后修饰

    Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.
  • 细胞定位

    Cytoplasm.
  • Target information above from: UniProt accession P55212 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 数据库链接

    • Entrez Gene: 839 Human
    • Entrez Gene: 83584 Rat
    • Omim: 601532 Human
    • SwissProt: P55212 Human
    • SwissProt: O35397 Rat
    • Unigene: 3280 Human
    • Unigene: 654616 Human
    • Unigene: 88160 Rat
    • 别名

      • active caspase 6 antibody
      • Apoptotic protease Mch-2 antibody
      • Apoptotic protease MCH2 antibody
      • CASP-6 antibody
      • CASP6 antibody
      • CASP6_HUMAN antibody
      • Caspase 6 apoptosis related cysteine peptidase antibody
      • Caspase-6 subunit p11 antibody
      • MCH2 antibody
      see all

    实验方案

    • Western blot protocols

    Click here to view the general protocols

    数据表及文件

    • Datasheet
    • SDS
  • 文献 (3)

    发表研究结果有使用 ab2326?请让我们知道,以便我们可以引用本数据表中的参考文章。

    ab2326 被引用在 3 文献中.

    • He Y  et al. CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. Cell Death Dis 11:358 (2020). PubMed: 32398664
    • Zhou J  et al. CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1. Cell Death Dis 10:885 (2019). PubMed: 31767835
    • Li X  et al. Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus. Antioxid Redox Signal 21:1675-92 (2014). Mouse . PubMed: 24483844

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    1-4 of 4 Abreviews or Q&A

    Question


    Do you have an image (i.e. western blot) to show the 18kDa band? What is your company's policy regarding
    antibodies?
    Thanks!

    Read More

    Abcam community

    Verified customer

    Asked on Apr 12 2012

    Answer

    Thanks for your enquiry.

    I am sorry but we do not have a western blot available for this antibody.

    When you refer to Abcam's "policy regarding antibodies", I presume you mean a guarantee. We do have a guarantee which we refer to as the Abpromise. In general, it states we guarantee the antibody to perform as noted on the datasheet. If it does not, we encourage you to contact us within 6 months of receiving the antibody and we'll do our best to help troubleshoot any issues. However, if the antibody still does not perform as expected, we are happy to offer a replacement, credit or refund.

    For complete information, please see the following link:

    https://www.abcam.com/abpromise

    I hope this is helpful. Please contact me again if you have any further questions.

    Read More

    Abcam Scientific Support

    回复于 Apr 12 2012

    Question

    I was wondering whether or not this antibody will only react with activated Caspase 6?

    Read More

    Abcam community

    Verified customer

    Asked on Apr 11 2012

    Answer

    This antibody reacts specifically to the large sub-unit (18 kDa) of the active caspase-6.

    I hope this is helpful. Please contact me again if you have any further questions.

    Read More

    Abcam Scientific Support

    回复于 Apr 11 2012

    Immunocytochemistry/ Immunofluorescence abreview for Anti-active Caspase 6 antibody

    Poor
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Human Cell (HeLa)
    Specification
    HeLa
    Fixative
    Paraformaldehyde
    Permeabilization
    Yes - 0.5% Triton X100 in PBS
    Read More

    Dr. Kirk Mcmanus

    Verified customer

    提交于 Oct 14 2008

    Question

    Do any of your caspase 6 (active form) antibodies work for IHC on perfused brain?

    Read More

    Abcam community

    Verified customer

    Asked on Oct 13 2003

    Answer

    We have three caspase 6 antibodies, none have been tested in IHC.

    Read More

    Asdf Edo

    Abcam Scientific Support

    回复于 Oct 13 2003

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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