Anti-CHRNB4抗体(ab129276)
Key features and details
- Goat polyclonal to CHRNB4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-CHRNB4抗体
参阅全部 CHRNB4 一抗 -
描述
山羊多克隆抗体to CHRNB4 -
宿主
Goat -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Horse, Hamster, Cow, Dog, Pig, Gorilla, Opossum, Common marmoset, Elephant -
免疫原
Synthetic peptide corresponding to Human CHRNB4 aa 87-101 (internal sequence) (Cysteine residue).
Sequence:DYRLTWNSSRYEGVN
Database link: NP_000741.1 -
阳性对照
- Human uterus tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab129276于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 2.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 2.5 - 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. -
序列相似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily. -
细胞定位
Cell junction > synapse > postsynaptic cell membrane. Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 282181 Cow
- Entrez Gene: 482110 Dog
- Entrez Gene: 1143 Human
- Entrez Gene: 108015 Mouse
- Entrez Gene: 25103 Rat
- Omim: 118509 Human
- SwissProt: Q8SPU6 Cow
- SwissProt: P30926 Human
see all -
别名
- acetylcholine receptor, nicotinic, beta 4 (neuronal) antibody
- ACHB4_HUMAN antibody
- AChR antibody
see all
图片
数据表及文件
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Datasheet download
文献 (5)
ab129276 被引用在 5 文献中.
- Durham E et al. Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells. Sci Rep 9:3805 (2019). PubMed: 30846819
- Seoane-Collazo P et al. Central nicotine induces browning through hypothalamic ? opioid receptor. Nat Commun 10:4037 (2019). PubMed: 31492869
- Qian J et al. Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs). PLoS One 13:e0190465 (2018). PubMed: 29293602
- Qian J et al. Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells. PLoS One 13:e0194089 (2018). PubMed: 29513745
- Qian J et al. Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. PLoS One 11:e0166565 (2016). ICC/IF ; Mouse . PubMed: 27846263