Key features and details
- Antimalarial; apoptosis and autophagy inhibitor
- CAS Number: 50-63-5
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
产品名称Chloroquine diphosphate，apoptosis and autophagy抑制剂
描述Antimalarial; apoptosis and autophagy抑制剂
Antimalarial agent. Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to Fe(II)-protoporphyrin IX (FP) to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion.
存放说明Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142116 被引用在 4 文献中.
- Goyal S et al. Inhibition of in vitro Ebola infection by anti-parasitic quinoline derivatives. F1000Res 9:268 (2020). PubMed: 32528661
- Xu S et al. Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer. Mol Cancer 18:89 (2019). PubMed: 30999914
- De Waele J et al. Poly(I:C) primes primary human glioblastoma cells for an immune response invigorated by PD-L1 blockade. Oncoimmunology 7:e1407899 (2018). PubMed: 29399410
- Prieto P et al. Activation of autophagy in macrophages by pro-resolving lipid mediators. Autophagy 11:1729-44 (2015). PubMed: 26506892