Anti-CETP抗体[ATM192] (ab2726)
Key features and details
- Mouse monoclonal [ATM192] to CETP
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG1
概述
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产品名称
Anti-CETP抗体[ATM192]
参阅全部 CETP 一抗 -
描述
小鼠单克隆抗体[ATM192] to CETP -
宿主
Mouse -
特异性
Detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues. -
经测试应用
适用于: ICC/IF, WBmore details -
种属反应性
与反应: Human
预测可用于: Cynomolgus monkey -
免疫原
Synthetic peptide corresponding to Human CETP aa 149-159.
Sequence:CDSGRVRTDAPD
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Purified from TCS -
克隆
单克隆 -
克隆编号
ATM192 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF |
1/20.
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|
WB | (3) |
Use a concentration of 2 µg/ml. Predicted molecular weight: 55 kDa.
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说明 |
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ICC/IF
1/20. |
WB
Use a concentration of 2 µg/ml. Predicted molecular weight: 55 kDa. |
靶标
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功能
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. -
组织特异性
Expressed by the liver and secreted in plasma. -
疾病相关
Defects in CETP are a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
Defects in CETP are the cause of cholesteryl ester transfer protein deficiency (CETP deficiency) [MIM:607322]. This is an autosomal dominant condition associated with increased HDL cholesterol levels. -
序列相似性
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. -
细胞定位
Secreted > extracellular space. - Information by UniProt
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数据库链接
- Entrez Gene: 1071 Human
- Omim: 118470 Human
- SwissProt: P11597 Human
- Unigene: 89538 Human
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别名
- BPIFF antibody
- CETP antibody
- CETP_HUMAN antibody
see all
图片
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All lanes : Anti-CETP antibody [ATM192] (ab2726) at 2 µg/ml
Lane 1 : HT-29 whole cell extracts
Lane 2 : HCT 116 whole cell extracts
Secondary
All lanes : Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjµgate at 0.4 µg/ml
Predicted band size: 55 kDa -
Immunocytochemistry/Immunofluorescence analysis of CETP in HepG2 cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with ab2726 (1:20) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. CETP staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab2726 被引用在 4 文献中.
- Cho KH et al. Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study. Oxid Med Cell Longev 2018:4809525 (2018). PubMed: 29854085
- Park KH et al. Slim Body Weight Is Highly Associated With Enhanced Lipoprotein Functionality, Higher HDL-C, and Large HDL Particle Size in Young Women. Front Endocrinol (Lausanne) 9:406 (2018). PubMed: 30072955
- Niculescu LS et al. Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-?B and PKA signaling pathways. Biochem Biophys Res Commun 415:497-502 (2011). WB ; Human . PubMed: 22056562
- Thomas AP et al. Mouse monoclonal antipeptide antibodies specific for cholesteryl ester transfer protein (CETP). Hybridoma 15:359-64 (1996). PubMed: 8913785