Anti-CETP抗体[ATM192] (ab2726)
Key features and details
- Mouse monoclonal [ATM192] to CETP
- Suitable for: ICC/IF
- Reacts with: Rabbit, Human
- Isotype: IgG1
概述
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产品名称
Anti-CETP抗体[ATM192]
参阅全部 CETP 一抗 -
描述
小鼠单克隆抗体[ATM192] to CETP -
宿主
Mouse -
特异性
Detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues. -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Rabbit, Human
预测可用于: Cynomolgus monkey -
免疫原
Synthetic peptide corresponding to Human CETP aa 149-159.
Sequence:CDSGRVRTDAPD
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阳性对照
- WB,IP: human serum WB: Recombinant Human CETP protein (ab114408), human liver lysate
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常规说明
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
Purified from TCS -
克隆
单克隆 -
克隆编号
ATM192 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
Our Abpromise guarantee covers the use of ab2726 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF | 1/20. |
靶标
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功能
Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. -
组织特异性
Expressed by the liver and secreted in plasma. -
疾病相关
Defects in CETP are a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
Defects in CETP are the cause of cholesteryl ester transfer protein deficiency (CETP deficiency) [MIM:607322]. This is an autosomal dominant condition associated with increased HDL cholesterol levels. -
序列相似性
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. -
细胞定位
Secreted > extracellular space. - Information by UniProt
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数据库链接
- Entrez Gene: 1071 Human
- Omim: 118470 Human
- SwissProt: P11597 Human
- SwissProt: P22687 Rabbit
- Unigene: 89538 Human
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别名
- BPIFF antibody
- CETP antibody
- CETP_HUMAN antibody
see all
图片
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Immunocytochemistry/Immunofluorescence analysis of CETP in HepG2 cells. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with ab2726 (1:20) overnight at 4°C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. CETP staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
文献 (4)
ab2726 被引用在 4 文献中.
- Cho KH et al. Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double-Blinded, and Placebo-Controlled Study. Oxid Med Cell Longev 2018:4809525 (2018). PubMed: 29854085
- Park KH et al. Slim Body Weight Is Highly Associated With Enhanced Lipoprotein Functionality, Higher HDL-C, and Large HDL Particle Size in Young Women. Front Endocrinol (Lausanne) 9:406 (2018). PubMed: 30072955
- Niculescu LS et al. Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-?B and PKA signaling pathways. Biochem Biophys Res Commun 415:497-502 (2011). WB ; Human . PubMed: 22056562
- Thomas AP et al. Mouse monoclonal antipeptide antibodies specific for cholesteryl ester transfer protein (CETP). Hybridoma 15:359-64 (1996). PubMed: 8913785