Anti-Cellubrevin抗体(ab5789)
Key features and details
- Rabbit polyclonal to Cellubrevin
- Suitable for: WB
- Reacts with: Human, Recombinant fragment
- Isotype: IgG
概述
-
产品名称
Anti-Cellubrevin抗体
参阅全部 Cellubrevin 一抗 -
描述
兔多克隆抗体to Cellubrevin -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human, Recombinant fragment
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Mouse Cellubrevin aa 1-18.
Sequence:MSTGVPSGSSAATGSNRR
(Peptide available asab5861) -
阳性对照
- In Western Blot HeLa cell extract (ab7898) can be used as a positive control.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading...
-
纯度
Immunogen affinity purified -
Primary antibody说明
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, all VAMP isoform levels appear to be significantly reduced. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
应用 | Ab评论 | 说明 |
---|---|---|
WB | (1) |
1/500. Detects a band of approximately 13 kDa (predicted molecular weight: 12 kDa).
|
说明 |
---|
WB
1/500. Detects a band of approximately 13 kDa (predicted molecular weight: 12 kDa). |
靶标
-
功能
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. -
序列相似性
Belongs to the synaptobrevin family.
Contains 1 v-SNARE coiled-coil homology domain. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Membrane. Cell junction > synapse > synaptosome. - Information by UniProt
-
数据库链接
- Entrez Gene: 9341 Human
- Entrez Gene: 22319 Mouse
- Entrez Gene: 29528 Rat
- Omim: 603657 Human
- SwissProt: Q15836 Human
- SwissProt: P63024 Mouse
- SwissProt: P63025 Rat
- Unigene: 66708 Human
see all -
别名
- CEB antibody
- Cellubrevin antibody
- Synaptobrevin 3 antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (5)
ab5789 被引用在 5 文献中.
- Lasic E et al. Astrocyte Specific Remodeling of Plasmalemmal Cholesterol Composition by Ketamine Indicates a New Mechanism of Antidepressant Action. Sci Rep 9:10957 (2019). PubMed: 31358895
- Habtemichael EN et al. Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes. J Biol Chem 293:10466-10486 (2018). PubMed: 29773651
- Verboogen DRJ et al. Secretory vesicles of immune cells contain only a limited number of interleukin 6 molecules. FEBS Lett 592:1535-1544 (2018). PubMed: 29570778
- Verboogen DRJ et al. Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activation. Elife 6:N/A (2017). WB, ICC/IF ; Human . PubMed: 28524818
- Caceres PS et al. Vesicle-associated membrane protein 2 (VAMP2) but Not VAMP3 mediates cAMP-stimulated trafficking of the renal Na+-K+-2Cl- co-transporter NKCC2 in thick ascending limbs. J Biol Chem 289:23951-62 (2014). WB ; Rat . PubMed: 25008321